catalog number :
MBS422095
products full name :
Goat anti-PEBP4 Antibody
products short name :
[PEBP4]
products name syn :
[PEBP4; phosphatidylethanolamine-binding protein 4; CORK-1; CORK1; GWTM1933; MGC22776; PRO4408; cousin-of-RKIP 1 protein; PEBP4 antibody; phosphatidylethanolamine-binding protein 4 antibody; CORK-1 antibody; CORK1 antibody; GWTM1933 antibody; MGC22776 antibody; PRO4408 antibody; cousin-of-RKIP 1 protein antibody]
other names :
[phosphatidylethanolamine-binding protein 4; Phosphatidylethanolamine-binding protein 4; phosphatidylethanolamine-binding protein 4; phosphatidylethanolamine binding protein 4; Protein cousin-of-RKIP 1]
products gene name :
[PEBP4]
other gene names :
[PEBP4; PEBP4; CORK1; CORK-1; PEBP-4; hPEBP4; PRO4408; GWTM1933; HEL-S-300; CORK1; PEBP-4; hPEBP4]
uniprot entry name :
PEBP4_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human
sequence :
RERASEPKHKNQAE
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 4000. Western blot: Approx 26kDa band observed in Human Heart lysates (calculated MW of 25.7kDa according to NP_659399.2). Recommended concentration: 1-3ug/ml. An additional band of unknown identity was also consistently observed at 30kDa. This band was successfully blocked by incubation with the immunizing peptide. Immunohistochemistry: In paraffin embedded Human Pancreas shows staining consistent with lysosomes. Recommended concentration, 5-10ug/ml.
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Peptide with sequence C-RERASEPKHKNQAE, from the C Terminus of the protein sequence according to NP_659399.2. Epitope: C Terminus
ncbi acc num :
NP_659399.2
ncbi gb acc num :
NM_144962.2
ncbi summary :
The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008]
uniprot summary :
PEBP4: Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization. Belongs to the phosphatidylethanolamine-binding protein family. Protein type: Lipid-binding; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 8p21.3. Cellular Component: lysosome. Molecular Function: protein binding