antibody

Goat anti-Lubricin/PRG4 Antibody

MBS422087

0.1 mg

225 USD

polyclonal

goat

nonconjugated

ELISA, enzyme immunoassay

Antibody

Goat anti-Lubricin/PRG4 Antibody

Lubricin/PRG4

PRG4; proteoglycan 4; CACP; FLJ32635; HAPO; JCAP; MSF; SZP; bG174L6.2; Jacobs camptodactyly-arthropathy-pericarditis syndrome; articular superficial zone protein; bG174L6.2 (MSF: megakaryocyte stimulating factor); camptodactyly, arthropathy, coxa vara,; PRG4 antibody; proteoglycan 4 antibody; CACP antibody; FLJ32635 antibody; HAPO antibody; JCAP antibody; MSF antibody; SZP antibody; bG174L6.2 antibody; Jacobs camptodactyly-arthropathy-pericarditis syndrome antibody; articular superficial zone protein antibody; bG174L6.2 (MSF: megakaryocyte stimulating factor) antibody; camptodactyly; arthropathy; coxa vara; pericarditis syndrome antibody; lubricin antibody; megakaryocyte stimulating factor antibody; proteoglycan 4; (megakaryocyte stimulating factor; articular superficial zone protein; camptodactyly; arthropathy; coxa vara; pericarditis syndrome) antibody; Lubricin; Lubricin / PRG4

proteoglycan 4 isoform A; Proteoglycan 4; proteoglycan 4; proteoglycan 4; Lubricin; Megakaryocyte-stimulating factor; Superficial zone proteoglycan

PRG4

PRG4; PRG4; MSF; SZP; CACP; HAPO; JCAP; MSF; SZP

PRG4_HUMAN

Polyclonal

Goat

Expected from sequence similarity: Human

1404

DYESFCAEVHNP

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Preliminary experiments in Human Bone Marrow lysates gave no specific signal but low background (at antibody concentration up to 0.3ug/ml).

Immunogen: Peptide with sequence DYESFCAEVHNP, from the internal region of the protein sequence according to NP_005798.2. Epitope: Internal region

67190163

NP_005798.2

NM_005807.3

146,468 Da

The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

PRG4: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Defects in PRG4 are the cause of camptodactyly- arthropathy-coxa vara-pericarditis syndrome (CACP); also known as Jacobs syndrome. CACP is an autosomal recessive disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1q25-q31. Cellular Component: extracellular region. Molecular Function: polysaccharide binding; scavenger receptor activity. Biological Process: cell proliferation; immune response; receptor-mediated endocytosis. Disease: Camptodactyly-arthropathy-coxa Vara-pericarditis Syndrome

0.1 mg

225 USD