catalog number :
MBS422085
products full name :
Goat anti-ABCA2 Antibody
products short name :
ABCA2
products name syn :
ABCA2; ATP-binding cassette; sub-family A (ABC1); member 2; ABC2; MGC129761; ATP-binding cassette; sub-family A; member 2; OTTHUMP00000064733; ATP-binding cassette, sub-family A (ABC1), member 2; ABC2; MGC129761; ATP-binding cassette, sub-family A, member 2; OTTHUMP00000064733
other names :
ATP-binding cassette sub-family A member 2 isoform a; ATP-binding cassette sub-family A member 2; ATP-binding cassette sub-family A member 2; ATP-binding cassette 2; ATP-binding cassette transporter 2; ATP-binding cassette, sub-family A, member 2; ATP-binding cassette, sub-family A (ABC1), member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2
products gene name :
ABCA2
other gene names :
ABCA2; ABCA2; ABC2; ABC2; KIAA1062; ATP-binding cassette 2
uniprot entry name :
ABCA2_HUMAN
reactivity :
Human, Mouse, Rat
sequence :
KKQSDNLEQQETEP
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Western Blot: Preliminary experiments gave an approx 35kDa band in Human Brain (Amygdala, Frontal Cortex, Hippocampus and Substantia Nigra) lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 270kDa according to NP_001597.2 and of 273kDa according to.NP_997698.1. The 35kDa band was successfully blocked by incubation with the immunizing peptide. Peptide ELISA: antibody detection limit dilution 1:2000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-KKQSDNLEQQETEP, from the internal region of the protein sequence according to NP_001597.2; NP_997698.1. Corresponding Immunizing Peptide: Catalog #MBS425936
other info2 :
Important Note: This antibody is expected to recognize both reported isoforms (NP_001597.2; NP_997698.1).
ncbi acc num :
NP_001597.2
ncbi gb acc num :
NM_001606.4
ncbi mol weight :
269,988 Da
ncbi pathways :
ABC Transporters Pathway 83035!!ABC Transporters Pathway 436!!ABC-family Proteins Mediated Transport Pathway 106573!!ABCA Transporters In Lipid Homeostasis Pathway 477112!!Lysosome Pathway 99052!!Lysosome Pathway 96865!!Transmembrane Transport Of Small Molecules Pathway 106572
ncbi summary :
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]