Goat anti-BMAL1/ARNTL Antibody | MyBioSource MBS422067 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-BMAL1/ARNTL Antibody

catalog :

MBS422067

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow, common platanna

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; common platanna; fig 2	Curran K, Allen L, Porter B, Dodge J, Lope C, Willadsen G, et al. Circadian genes, xBmal1 and xNocturnin, modulate the timing and differentiation of somites in Xenopus laevis. PLoS ONE. 2014;9:e108266 pubmed publisher

product information

catalog number :

MBS422067

products type :

Antibody

products full name :

Goat anti-BMAL1/ARNTL Antibody

products short name :

BMAL1/ARNTL

products name syn :

ARNTL; BMAL1; aryl hydrocarbon receptor nuclear translocator-like; BMAL1c; JAP3; MGC47515; MOP3; PASD3; TIC; ARNT-like protein 1, brain and muscle; bHLH-PAS protein JAP3; basic-helix-loop-helix-PAS orphan MOP3; member of PAS superfamily 3; ARNTL antibody; BMAL1 antibody; aryl hydrocarbon receptor nuclear translocator-like antibody; BMAL1c antibody; JAP3 antibody; MGC47515 antibody; MOP3 antibody; PASD3 antibody; TIC antibody; ARNT-like protein 1; brain and muscle antibody; bHLH-PAS protein JAP3 antibody; basic-helix-loop-helix-PAS orphan MOP3 antibody; member of PAS superfamily 3 antibody; BMAL1 / ARNTL

other names :

aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a; Aryl hydrocarbon receptor nuclear translocator-like protein 1; aryl hydrocarbon receptor nuclear translocator-like protein 1; aryl hydrocarbon receptor nuclear translocator like; Basic-helix-loop-helix-PAS protein MOP3; Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; bHLHe5; Member of PAS protein 3; PAS domain-containing protein 3; bHLH-PAS protein JAP3

products gene name :

ARNTL

products gene name syn :

BMAL1

other gene names :

ARNTL; ARNTL; TIC; JAP3; MOP3; BMAL1; PASD3; BMAL1c; bHLHe5; BHLHE5; BMAL1; MOP3; PASD3; bHLHe5

uniprot entry name :

BMAL1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

sequence length :

625

sequence :

REKITTNCYKFKIKD

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx.70+75kDa bands observed in Human Brain (Cerebellum) lysates (calculated MW of 68.7kDa according to NP_001169.3 and 64.1kDa according to NP_001025444.1). Recommended concentration: 0.3-1ug/ml.

other info1 :

Immunogen: Peptide with sequence REKITTNCYKFKIKD, from the internal region of the protein sequence according to NP_001169.3; NP_001025444.1. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognize both reported isoforms (NP_001025444.1; NP_001025443.1). Reported variants represent identical protein (NP_001025443.1; NP_001169.3).

ncbi gi num :

42716311

ncbi acc num :

NP_001169.3

ncbi gb acc num :

NM_001178.5

ncbi mol weight :

64,136 Da

ncbi pathways :

BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (1269872); Circadian Clock Pathway (1269871); Circadian Rhythm Pathway (83084); Circadian Rhythm Pathway (495); Circadian Rhythm Pathway (137978); Diurnally Regulated Genes With Circadian Orthologs Pathway (198813); Dopaminergic Synapse Pathway (469199); Dopaminergic Synapse Pathway (469185); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (1270010); Herpes Simplex Infection Pathway (377873)

ncbi summary :

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

uniprot summary :

BMAL1: aryl hydrocarbon receptor nuclear translocator-like protein. A circadian regulatory protein and substrate of casein kinase I epsilon. Heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Seven splice isoforms have been reported. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 11p15. Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus; PML body; transcription factor complex. Molecular Function: aryl hydrocarbon receptor binding; bHLH transcription factor binding; DNA binding; Hsp90 protein binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding. Biological Process: circadian regulation of gene expression; circadian rhythm; maternal process involved in parturition; negative regulation of fat cell differentiation; negative regulation of TOR signaling pathway; negative regulation of transcription, DNA-dependent; positive regulation of circadian rhythm; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; protein import into nucleus, translocation; regulation of cell cycle; regulation of hair cycle; regulation of insulin secretion; regulation of neurogenesis; regulation of protein catabolic process; regulation of transcription, DNA-dependent; response to redox state; spermatogenesis; transcription from RNA polymerase II promoter

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage