antibody

Goat anti-F2R/PAR1 Antibody

MBS422062

0.1 mg

300 USD

polyclonal

goat

nonconjugated

western blot, enzyme immunoassay

Antibody

Goat anti-F2R/PAR1 Antibody

F2R/PAR1

F2R; coagulation factor II (thrombin) receptor; CF2R; HTR; PAR1; TR; coagulation factor II receptor; protease-activated receptor 1; thrombin receptor; F2R antibody; coagulation factor II (thrombin) receptor antibody; CF2R antibody; HTR antibody; PAR1 antibody; TR antibody; coagulation factor II receptor antibody; protease-activated receptor 1 antibody; thrombin receptor antibody; F2R / PAR1

proteinase-activated receptor 1 isoform 1; Proteinase-activated receptor 1; proteinase-activated receptor 1; coagulation factor II thrombin receptor; Coagulation factor II receptor; Thrombin receptor

F2R

PAR1

F2R; F2R; TR; HTR; CF2R; PAR1; PAR-1; CF2R; PAR1; TR; PAR-1

PAR1_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human

425

TRARRPESKATNAT

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 48kDa band observed in lysates of cell line HeLa (calculated MW of 47.4kDa according to NP_001983.2). Recommended concentration: 0.5-2ug/ml.

Immunogen: Peptide with sequence C-TRARRPESKATNAT, from the Internal region (near N Terminus) of the protein sequence according to NP_001983.2. Epitope: Internal region (near N Terminus)

166362740

NP_001983.2

NM_001992.4

47,441 Da

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Common Pathway Of Fibrin Clot Formation (1269371); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Formation Of Fibrin Clot (Clotting Cascade) Pathway (1269368)

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

PAR1: a G-protein coupled high-affinity receptor for activated thrombin or trypsin. Coupled to G proteins that stimulate phosphoinositide hydrolysis. Coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelet activation and in vascular development. Protein type: Cell development/differentiation; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR. Chromosomal Location of Human Ortholog: 5q13. Cellular Component: caveola; cell surface; cytosol; early endosome; extracellular region; Golgi apparatus; integral to plasma membrane; late endosome; neuromuscular junction; plasma membrane; postsynaptic membrane. Molecular Function: G-protein alpha-subunit binding; G-protein beta-subunit binding; G-protein coupled receptor activity; protein binding; receptor binding; thrombin receptor activity. Biological Process: activation of MAPKK activity; anatomical structure morphogenesis; blood coagulation; caspase activation; connective tissue replacement during inflammatory response; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); establishment of synaptic specificity at neuromuscular junction; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); homeostasis of number of cells within a tissue; inflammatory response; negative regulation of cell proliferation; negative regulation of glomerular filtration; negative regulation of neuron apoptosis; platelet activation; platelet dense granule organization and biogenesis; positive regulation of blood coagulation; positive regulation of calcium ion transport; positive regulation of caspase activity; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JAK-STAT cascade; positive regulation of MAPKKK cascade; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of Rho protein signal transduction; positive regulation of smooth muscle contraction; positive regulation of transcription, DNA-dependent; positive regulation of vasoconstriction; protein kinase C activation; regulation of blood coagulation; regulation of interleukin-1 beta production; regulation of sensory perception of pain; release of sequestered calcium ion into cytosol; response to lipopolysaccharide; response to wounding; STAT protein nuclear translocation; tyrosine phosphorylation of STAT protein

0.1 mg

300 USD