catalog number :
MBS422033
products full name :
Goat anti-AAK1 Antibody
products short name :
AAK1
products name syn :
AAK1; AP2 associated kinase 1; DKFZp686F03202; DKFZp686K16132; FLJ23712; FLJ25931; FLJ31060; FLJ42882; FLJ45252; KIAA1048; MGC138170; MGC164568; MGC164570; adaptor-associated kinase 1; AP2 associated kinase 1; DKFZp686F03202; DKFZp686K16132; FLJ23712; FLJ25931; FLJ31060; FLJ42882; FLJ45252; KIAA1048; MGC138170; MGC164568; MGC164570; adaptor-associated kinase 1
other names :
AP2-associated protein kinase 1; AP2-associated protein kinase 1; AP2-associated protein kinase 1; adaptor-associated kinase 1; AP2 associated kinase 1; Adaptor-associated kinase 1
products gene name :
AAK1
other gene names :
AAK1; AAK1; KIAA1048
uniprot entry name :
AAK1_HUMAN
reactivity :
Human, Mouse, Rat, Cow
sequence :
GSPRTSQQNVYNPSE
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 100kDa band observed in Human Brain (Amygdala and Cerebellum) lysates (calculated MW of 104kDa according to NP_055726.3). Recommended concentration: 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-GSPRTSQQNVYNPSE, from the internal region of the protein sequence according to NP_055726.3.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425104
ncbi acc num :
NP_055726.3
ncbi gb acc num :
NM_014911.3
ncbi mol weight :
93,578 Da
ncbi summary :
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]