Goat anti-TDP-43 Antibody | MyBioSource MBS422006 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-TDP-43 Antibody

catalog :

MBS422006

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS422006

products type :

Antibody

products full name :

Goat anti-TDP-43 Antibody

products short name :

TDP-43

products name syn :

TARDBP; TAR DNA binding protein; ALS10; TDP-43; OTTHUMP00000002171; TAR DNA-binding protein-43; TARDBP antibody; TAR DNA binding protein antibody; ALS10 antibody; TDP-43 antibody; OTTHUMP00000002171 antibody; TAR DNA-binding protein-43 antibody; TDP-43

other names :

TAR DNA-binding protein 43; TAR DNA-binding protein 43; TAR DNA-binding protein 43; TAR DNA binding protein

products gene name :

TARDBP

products gene name syn :

TDP-43

other gene names :

TARDBP; TARDBP; ALS10; TDP-43; TDP43; TDP-43

uniprot entry name :

TADBP_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

sequence length :

414

sequence :

HISNAEPKHNSNRQ

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: approx. 45kDa band observed in lysates of cell lines Jurkat and NIH3T3 (calculated MW of 44.7kDa according to NP_031401.1). A slightly larger protein is detected in some regions of the brain. Recommended concentration: 0.3-1ug/ml.

other info1 :

Immunogen: Peptide with sequence C-HISNAEPKHNSNRQ, from the internal region of the protein sequence according to NP_031401.1. Epitope: Internal region

ncbi gi num :

6678271

ncbi acc num :

NP_031401.1

ncbi gb acc num :

NM_007375.3

ncbi mol weight :

31,808 Da

ncbi summary :

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

uniprot summary :

TARDBP: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. Homodimer. Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of six contiguous repeats. Interacts with ATNX2; the interaction is RNA-dependent. Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. 3 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding. Chromosomal Location of Human Ortholog: 1p36.22. Cellular Component: cytoplasm; nuclear speck; nucleoplasm; nucleus; perichromatin fibrils. Molecular Function: double-stranded DNA binding; identical protein binding; mRNA 3'-UTR binding; nucleotide binding; protein binding; RNA binding; transcription factor activity. Biological Process: mRNA processing; negative regulation of protein amino acid phosphorylation; nuclear fragmentation during apoptosis; positive regulation of insulin secretion; positive regulation of transcription from RNA polymerase II promoter; regulation of cell cycle; RNA splicing; transcription from RNA polymerase II promoter. Disease: Amyotrophic Lateral Sclerosis 10, With Or Without Frontotemporal Dementia

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage