Goat anti-F11R/JAM-A Antibody | MyBioSource MBS421976 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-F11R/JAM-A Antibody

catalog :

MBS421976

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421976

products type :

Antibody

products full name :

Goat anti-F11R/JAM-A Antibody

products short name :

F11R/JAM-A

products name syn :

F11R; F11 receptor; CD321; JAM; JAM-1; JAM-A; JAM1; JAMA; JCAM; KAT; PAM-1; OTTHUMP00000027880; OTTHUMP00000027881; junctional adhesion molecule 1; junctional adhesion molecule A; platelet F11 receptor; platelet adhesion molecule; F11R antibody; F11 receptor antibody; CD321 antibody; JAM antibody; JAM-1 antibody; JAM-A antibody; JAM1 antibody; JAMA antibody; JCAM antibody; KAT antibody; PAM-1 antibody; OTTHUMP00000027880 antibody; OTTHUMP00000027881 antibody; junctional adhesion molecule 1 antibody; junctional adhesion molecule A antibody; platelet F11 receptor antibody; platelet adhesion molecule antibody; F11R / JAM-A

other names :

junctional adhesion molecule A; Junctional adhesion molecule A; junctional adhesion molecule A; F11 receptor; Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD_antigen: CD321

products gene name :

F11R

products gene name syn :

JAM-A

other gene names :

F11R; F11R; JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1; JAM1; JCAM; JAM-A; JAM-1; PAM-1

uniprot entry name :

JAM1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig

sequence length :

299

sequence :

QPSARSEGEFKQTS

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 2000. Western Blot: Approx 38kDa band observed in Human Peripheral Blood Mononucleocyte lysates (calculated MW of 32.6kDa according to NP_058642.1). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 0.3-2ug/ml.

other info1 :

Immunogen: Peptide with sequence C-QPSARSEGEFKQTS, from the C Terminus of the protein sequence according to NP_058642.1. Epitope: C Terminus

ncbi gi num :

8393638

ncbi acc num :

NP_058642.1

ncbi gb acc num :

NM_016946.4

ncbi mol weight :

27,208 Da

ncbi pathways :

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (1270232); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Cell-Cell Communication Pathway (1270231); Cell-cell Junction Organization Pathway (1270233); Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway (83102); Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway (515); Extracellular Matrix Organization Pathway (1270244); Hemostasis Pathway (1269340)

ncbi summary :

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

uniprot summary :

JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily. Protein type: Membrane protein, integral; Cell adhesion. Chromosomal Location of Human Ortholog: 1q21.2-q21.3. Cellular Component: cell junction; cytoplasmic vesicle; integral to membrane; intercellular junction; microtubule cytoskeleton; plasma membrane; tight junction. Molecular Function: PDZ domain binding; protein binding; viral receptor activity. Biological Process: actomyosin structure organization and biogenesis; cell adhesion; entry of virus into host cell; extracellular matrix organization and biogenesis; inflammatory response; intestinal absorption; leukocyte migration; positive regulation of blood pressure; positive regulation of GTPase activity; regulation of cytokine production; response to radiation; transforming growth factor beta receptor signaling pathway

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage