catalog number :
MBS421964
products full name :
Goat anti-DLG4 / PSD95 Antibody
products short name :
DLG4/PSD95
products name syn :
DLG4; discs; large homolog 4 (Drosophila); FLJ97752; FLJ98574; PSD95; SAP90; Tax interaction protein 15; discs large homolog 4; post-synaptic density protein 95; synapse-associated protein 90; DLG4; discs, large homolog 4 (Drosophila); FLJ97752; FLJ98574; PSD95; SAP90; Tax interaction protein 15; discs large homolog 4; post-synaptic density protein 95; synapse-associated protein 90
other names :
disks large homolog 4 isoform 1; Disks large homolog 4; disks large homolog 4; discs large homolog 4; Tax interaction protein 15; synapse-associated protein 90; postsynaptic density protein 95; post-synaptic density protein 95; discs, large homolog 4 (Drosophila); Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90
products gene name :
DLG4
other gene names :
DLG4; DLG4; PSD95; SAP90; SAP-90; PSD95; PSD-95; SAP-90; SAP90
uniprot entry name :
DLG4_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 110kDa band observed in Rat Brain lysates (calculated MW of 80.5kDa according to Rat NP_062567.1).The observed molecular weight corresponds to earlier findings in literature with different antibodies (Chaudhury et al, Am J Physiol Gastrointest Liver Physiol. 2009 Aug 13. PMID: 19679819). Recommended concentration: 0.3-1ug/ml. Peptide ELISA: antibody detection limit dilution 1:64000.
other info1 :
Epitope: Internal Region (Near C Terminus). Immunogen: Peptide with sequence C-EEQARKAFDRATK, from the internal region (near C-Terminus) of the protein sequence according to NP_001356.1; NP_001122299.1. Corresponding Immunizing Peptide: Catalog #MBS425178
other info2 :
Important Note: This antibody is expected to recognize both reported isoforms (NP_001356.1; NP_001122299.1)
ncbi acc num :
NP_001356.1
ncbi gb acc num :
NM_001365.3
ncbi mol weight :
80,125 Da
ncbi pathways :
Activation Of Ca-permeable Kainate Receptor Pathway 161046!!Activation Of Kainate Receptors Upon Glutamate Binding Pathway 161043!!Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway 161033!!Axon Guidance Pathway 105688!!CREB Phosphorylation Through The Activation Of CaMKII Pathway 161040!!CREB Phosphorylation Through The Activation Of Ras Pathway 161036!!Cocaine Addiction Pathway 546258!!Cocaine Addiction Pathway 546273!!Developmental Biology Pathway 477129!!ErbB4 Signaling Events Pathway 137991
ncbi summary :
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]