catalog number :
MBS421940
products full name :
Goat anti-UBR4 / ZUBR1 Antibody
products short name :
UBR4/ZUBR1
products name syn :
UBR4; ubiquitin protein ligase E3 component n-recognin 4; FLJ41863; KIAA0462; KIAA1307; RBAF600; ZUBR1; p600; retinoblastoma-associated factor 600; retinoblastoma-associated factor 600-like protein; zinc finger; UBR1 type 1; UBR4; ubiquitin protein ligase E3 component n-recognin 4; FLJ41863; KIAA0462; KIAA1307; RBAF600; ZUBR1; p600; retinoblastoma-associated factor 600; retinoblastoma-associated factor 600-like protein; zinc finger, UBR1 type 1
other names :
E3 ubiquitin-protein ligase UBR4; E3 ubiquitin-protein ligase UBR4; E3 ubiquitin-protein ligase UBR4; N-recognin-4; zinc finger UBR1-type protein 1; retinoblastoma-associated factor of 600 kDa; retinoblastoma-associated factor 600-like protein; ubiquitin protein ligase E3 component n-recognin 4; 600 kDa retinoblastoma protein-associated factor; N-recognin-4; Retinoblastoma-associated factor of 600 kDa; RBAF600; p600; Zinc finger UBR1-type protein 1
products gene name :
UBR4
other gene names :
UBR4; UBR4; p600; ZUBR1; RBAF600; KIAA0462; KIAA1307; RBAF600; ZUBR1; RBAF600; p600
uniprot entry name :
UBR4_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow
sequence :
NTTRATSREEKNLQ
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunohistochemistry (IHC)
app notes :
Immunohistochemistry: In paraffin embedded Spleen shows various types of subnuclear staining in select splenocytes and additional membrane plus cytoplasm staining elsewhere. Recommended concentration, 5-10ug/ml. Peptide ELISA: antibody detection limit dilution 1:128000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-NTTRATSREEKNLQ, from the C Terminus of the protein sequence according to NP_065816.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425338
ncbi acc num :
NP_065816.2
ncbi gb acc num :
NM_020765.2
ncbi mol weight :
23,957 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Antigen Processing: Ubiquitination Proteasome Degradation Pathway 366162!!Class I MHC Mediated Antigen Processing Presentation Pathway 366161!!Immune System Pathway 106386!!Viral Carcinogenesis Pathway 658418!!Viral Carcinogenesis Pathway 662842
ncbi summary :
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]