antibody

Goat anti-Sterol carrier protein 2 Antibody

MBS421938

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

western blot, immunohistochemistry, enzyme immunoassay

Antibody

Goat anti-Sterol carrier protein 2 Antibody

Sterol carrier protein 2

SCP2; sterol carrier protein 2; DKFZp686C12188; DKFZp686D11188; NLTP; NSL-TP; SCPX; nonspecific lipid-transfer protein; sterol carrier protein X; SCP2; sterol carrier protein 2; DKFZp686C12188; DKFZp686D11188; NLTP; NSL-TP; SCPX; nonspecific lipid-transfer protein; sterol carrier protein X

non-specific lipid-transfer protein isoform 2; Non-specific lipid-transfer protein; non-specific lipid-transfer protein; sterol carrier protein X; propanoyl-CoA C-acyltransferase; sterol carrier protein 2; Propanoyl-CoA C-acyltransferase; SCP-chi; SCPX; Sterol carrier protein 2; SCP-2; Sterol carrier protein X; SCP-X

SCP2

SCP2; SCP2; NLTP; SCPX; SCP-2; SCP-X; NSL-TP; SCP-CHI; NSL-TP; SCP-2; SCP-X

NLTP_HUMAN

Polyclonal

Goat

Human, Mouse, Rat, Dog, Pig, Cow

322

KNHKHSVNNPYSQ

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry: In paraffin embedded Human Liver shows speckled cytoplasm staining in hepatocytes. Recommended concentration, 3-6ug/ml. Western Blot: Preliminary experiments gave an approx 50kDa band in Human Liver lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 59.0kDa according to NP_001007099.1 and of 6.7kDa according to NP_002970.2. The 28kDa band was successfully blocked by incubation with the immunizing peptide. Peptide ELISA: antibody detection limit dilution 1:32000.

Epitope: Internal Region. Immunogen: Peptide with sequence C-KNHKHSVNNPYSQ, from the internal region of the protein sequence according to NP_001007099.1; NP_002970.2; NP_001180528.1; NP_001180529.1; NP_001180546.1. Corresponding Immunizing Peptide: Catalog #MBS426867

Important Note: This antibody is expected to recognize isoform 1, 2, 6, 7 and 8 (NP_002970.2; NP_001007099.1; NP_001180529.1; NP_001180528.1; NP_001180546.1 respectively),

55956775

NP_001007099.1

NM_001007098.2

56,497 Da

Beta-oxidation Of Pristanoyl-CoA Pathway 106138!!Bile Acid And Bile Salt Metabolism Pathway 106144!!Bile Acid Biosynthesis, Cholesterol = Cholate/chenodeoxycholate Pathway 413432!!Bile Acid Biosynthesis, Cholesterol = Cholate/chenodeoxycholate Pathway 468297!!DNA Damage Response (only ATM Dependent) Pathway 198827!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Mitochondrial LC-Fatty Acid Beta-Oxidation Pathway 198817!!PPAR Signaling Pathway 83042

This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]

0.1 mg

290 USD