antibody

Goat anti-KCNQ1 Antibody

MBS421936

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

western blot, enzyme immunoassay

Antibody

Goat anti-KCNQ1 Antibody

KCNQ1

KCNQ1; potassium voltage-gated channel, KQT-like subfamily, member 1; ATFB1; FLJ26167; JLNS1; KCNA8; KCNA9; KVLQT1; Kv1.9; Kv7.1; LQT; LQT1; RWS; SQT2; WRS; Jervell and Lange-Nielsen syndrome 1; kidney and cardiac voltage dependend K+ channel; long (elect; KCNQ1 antibody; potassium voltage-gated channel; KQT-like subfamily; member 1 antibody; ATFB1 antibody; FLJ26167 antibody; JLNS1 antibody; KCNA8 antibody; KCNA9 antibody; KVLQT1 antibody; Kv1.9 antibody; Kv7.1 antibody; LQT antibody; LQT1 antibody; RWS antibody; SQT2 antibody; WRS antibody; Jervell and Lange-Nielsen syndrome 1 antibody; kidney and cardiac voltage dependend K+ channel antibody; long (electrocardiographic) QT syndrome; Ward-Romano syndrome 1 antibody; slow delayed rectifier channel subunit antibody

potassium voltage-gated channel subfamily KQT member 1 isoform 1; Potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel subfamily Q member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1

KCNQ1

KCNQ1; KCNQ1; LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1

KCNQ1_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

676

EQLTVPRRGPDEGS

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 16000.

Immunogen: Peptide with sequence C-EQLTVPRRGPDEGS, from the C Terminus of the protein sequence according to NP_000209.2; NP_861463.1. Epitope: C Terminus

Note: This antibody is expected to recognize both reported isoforms (NP_000209.2; NP_861463.1).

32479527

NP_000209.2

NM_000218.2

61,474 Da

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Cardiac Conduction Pathway (1339115); Cholinergic Synapse Pathway (217716); Gastric Acid Secretion Pathway (154409); Gastric Acid Secretion Pathway (154383); Muscle Contraction Pathway (1269868); Neuronal System Pathway (1268763); Pancreatic Secretion Pathway (169306); Pancreatic Secretion Pathway (169295)

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

Kv7.1: a voltage-gated potassium channel protein required for the repolarization phase of the cardiac action potential. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea. Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries. Three alternatively spliced isoforms have been described. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: basolateral plasma membrane; cytoplasm; cytoplasmic vesicle membrane; early endosome; endoplasmic reticulum; late endosome; lipid raft; lysosome; plasma membrane; voltage-gated potassium channel complex. Molecular Function: calmodulin binding; delayed rectifier potassium channel activity; outward rectifier potassium channel activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein phosphatase 1 binding; voltage-gated potassium channel activity. Biological Process: cardiac muscle contraction; gene silencing; genetic imprinting; inner ear development; intestinal absorption; positive regulation of defense response to virus by host; positive regulation of heart rate; regulation of heart contraction; sensory perception of sound. Disease: Atrial Fibrillation, Familial, 3; Beckwith-wiedemann Syndrome; Jervell And Lange-nielsen Syndrome 1; Long Qt Syndrome 1; Short Qt Syndrome 2

0.1 mg

300 USD