catalog number :
MBS421867
products full name :
Goat anti-Connexin 30 / GJB6 Antibody
products short name :
Connexin 30/GJB6
products name syn :
GJB6; gap junction protein; beta 6; 30kDa; CX30; DFNA3; ED2; EDH; HED; OTTHUMP00000018096; OTTHUMP00000176870; OTTHUMP00000176871; OTTHUMP00000176872; connexin 30; ectodermal dysplasia 2; hidrotic (Clouston syndrome); gap junction protein; beta 6; gap junction protein; beta 6 (connexin 30); GJB6; gap junction protein, beta 6, 30kDa; CX30; DFNA3; ED2; EDH; HED; OTTHUMP00000018096; OTTHUMP00000176870; OTTHUMP00000176871; OTTHUMP00000176872; connexin 30; ectodermal dysplasia 2, hidrotic (Clouston syndrome); gap junction protein, beta 6; gap junction protein, beta 6 (connexin 30)
other names :
gap junction beta-6 protein; Gap junction beta-6 protein; gap junction beta-6 protein; connexin 30; connexin-30; gap junction protein, beta 6 (connexin 30); ectodermal dysplasia 2, hidrotic (Clouston syndrome); gap junction protein, beta 6, 30kDa; Connexin-30; Cx30
products gene name :
GJB6
other gene names :
GJB6; GJB6; ED2; EDH; HED; CX30; HED2; DFNA3; ECTD2; DFNA3B; DFNB1B; Cx30
uniprot entry name :
CXB6_HUMAN
reactivity :
Human, Mouse, Rat, Cow
sequence :
RSKRAQTQKNHPNH
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Western Blot: Preliminary experiments gave an approx 14kDa band in Human Brain (Cerebellum) and Rat Brain lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 30.4kDa according to NP_006774.2. The 14kDa band was successfully blocked by incubation with the immunizing peptide. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-RSKRAQTQKNHPNH, from the internal region of the protein sequence according to NP_006774.2. Corresponding Immunizing Peptide: Catalog #MBS426617
other info2 :
Important Note: Reported variants represent identical protein: NP_006774.2, NP_001103691.1, NP_001103689.1, NP_001103690.1
ncbi acc num :
NP_006774.2
ncbi gb acc num :
NM_006783.4
ncbi mol weight :
30,387 Da
ncbi pathways :
Calcium Regulation In The Cardiac Cell Pathway 198906!!Gap Junction Assembly Pathway 105928!!Gap Junction Trafficking Pathway 105927!!Gap Junction Trafficking And Regulation Pathway 105926!!Membrane Trafficking Pathway 106160
ncbi summary :
Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]