Goat anti-TXK Antibody | MyBioSource MBS421849 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-TXK Antibody

catalog :

MBS421849

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421849

products type :

Antibody

products full name :

Goat anti-TXK Antibody

products short name :

TXK

products name syn :

TXK; TXK tyrosine kinase; RLK; TKL; BTKL; PSCTK5; PTK4; PTK4 protein tyrosine kinase 4; tyrosine kinase; MGC22473; TXK antibody; TXK tyrosine kinase antibody; RLK antibody; TKL antibody; BTKL antibody; PSCTK5 antibody; PTK4 antibody; PTK4 protein tyrosine kinase 4 antibody; tyrosine kinase antibody; MGC22473 antibody

other names :

tyrosine-protein kinase TXK; Tyrosine-protein kinase TXK; tyrosine-protein kinase TXK; TXK tyrosine kinase; Protein-tyrosine kinase 4; Resting lymphocyte kinase

products gene name :

TXK

other gene names :

TXK; TXK; RLK; TKL; BTKL; PTK4; PSCTK5; PTK4; RLK

uniprot entry name :

TXK_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Dog, Pig, Cow

sequence length :

527

sequence :

ELLRAVTEIAETW

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Approx 60kDa band observed in Human Tonsil and Thymus and Spleen lysates (calculated MW of 61.3kDa according to NP_003319.2). Recommended concentration: 0.3-1ug/ml.

other info1 :

Immunogen: Peptide with sequence C-ELLRAVTEIAETW, from the C Terminus of the protein sequence according to NP_003319.2. Epitope: C Terminus

ncbi gi num :

148596974

ncbi acc num :

NP_003319.2

ncbi gb acc num :

NM_003328.2

ncbi mol weight :

61,258 Da

ncbi pathways :

FCERI Mediated Ca+2 Mobilization Pathway (1269300); Fc Epsilon Receptor (FCERI) Signaling Pathway (1269298); Focal Adhesion Pathway (198795); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494)

uniprot summary :

TXK: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. Protein type: Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; Kinase, protein; TK group; Tec family. Chromosomal Location of Human Ortholog: 4p12. Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; nucleus. Molecular Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; protein binding; receptor binding. Biological Process: adaptive immune response; cell differentiation; cytokine production; integrin-mediated signaling pathway; phospholipase C activation; positive regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; tissue regeneration; transcription from RNA polymerase II promoter; transmembrane receptor protein tyrosine kinase signaling pathway

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage