Goat anti-IA2 Antibody | MyBioSource MBS421847 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-IA2 Antibody

catalog :

MBS421847

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421847

products type :

Antibody

products full name :

Goat anti-IA2 Antibody

products short name :

IA2

products name syn :

IA-2; protein tyrosine phosphatase, receptor type, N; FLJ16131; IA-2/PTP; IA2; ICA512; R-PTP-N; islet antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; IA-2 antibody; protein tyrosine phosphatase; receptor type; N antibody; FLJ16131 antibody; IA-2/PTP antibody; IA2 antibody; ICA512 antibody; R-PTP-N antibody; islet antigen 2 antibody; islet cell antigen 512 antibody; islet cell autoantigen 3 antibody; protein tyrosine phosphatase-like N antibody

other names :

receptor-type tyrosine-protein phosphatase-like N isoform 1; Receptor-type tyrosine-protein phosphatase-like N; receptor-type tyrosine-protein phosphatase-like N; protein tyrosine phosphatase, receptor type N; Islet cell antigen 512

products gene name :

PTPRN

products gene name syn :

IA2

other gene names :

PTPRN; PTPRN; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP; ICA3; ICA512; ICA 512

uniprot entry name :

PTPRN_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Mouse; Expected from sequence similarity: Human, Mouse, Rat

sequence length :

979

sequence :

QGEGNIKKNRHPD

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 110kDa band observed in lysates of cell line NIH 3T3 (calculated MW of 106kDa according to Human NP_002837.1 and Mouse NP_033011.2). Recommended concentration: 0.5-1.5ug/ml.

other info1 :

Immunogen: Peptide with sequence C-QGEGNIKKNRHPD, from the internal region of the protein sequence according to NP_002837.1. Epitope: Internal region

ncbi gi num :

4506321

ncbi acc num :

NP_002837.1

ncbi gb acc num :

NM_002846.3

ncbi mol weight :

96,261 Da

ncbi pathways :

Type I Diabetes Mellitus Pathway (83095); Type I Diabetes Mellitus Pathway (507)

ncbi summary :

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

uniprot summary :

PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 2q35-q36.1. Cellular Component: cell junction; cell soma; endosome; Golgi apparatus; integral to membrane; nerve terminal; perikaryon; plasma membrane; secretory granule; synapse; synaptic vesicle. Molecular Function: GTPase binding; protein binding; protein tyrosine phosphatase activity; spectrin binding. Biological Process: cytokine and chemokine mediated signaling pathway; insulin secretion; luteinization; protein amino acid dephosphorylation; response to cAMP; response to estrogen stimulus; response to insulin stimulus; response to reactive oxygen species

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage