catalog number :
MBS421843
products full name :
Goat anti-JAMC Antibody
products short name :
JAMC
products name syn :
JAM3; junctional adhesion molecule 3; FLJ14529; JAM-C; JAMC; junctional adhesion molecule C; JAM3; junctional adhesion molecule 3; FLJ14529; JAM-C; JAMC; junctional adhesion molecule C
other names :
junctional adhesion molecule C; Junctional adhesion molecule C; junctional adhesion molecule C; junctional adhesion molecule 3; JAM-2; Junctional adhesion molecule 3; JAM-3
products gene name :
JAM3
other gene names :
JAM3; JAM3; JAMC; JAM-2; JAM-3; JAM-C; JAM-C; JAM-3
uniprot entry name :
JAM3_HUMAN
sequence :
KQDGESYKNPGKPD
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Western Blot: Preliminary experiments in Human Brain (Cerebellum), Lung and PLacenta lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). Peptide ELISA: antibody detection limit dilution 1:2000.
other info1 :
Epitope: Internal Region (Near C Terminus). Immunogen: Peptide with sequence C-KQDGESYKNPGKPD, from the internal region (near C-Terminus) of the protein sequence according to NP_116190.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425024
ncbi acc num :
NP_116190.2
ncbi gb acc num :
NM_032801.3
ncbi mol weight :
29,223 Da
ncbi pathways :
Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway 83102!!Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway 515!!Extracellular Matrix Organization Pathway 576262!!Hemostasis Pathway 106028!!Integrin Cell Surface Interactions Pathway 106110!!Leukocyte Transendothelial Migration Pathway 83083!!Leukocyte Transendothelial Migration Pathway 494
ncbi summary :
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]