catalog number :
MBS421831
products full name :
Goat anti-ABHD12 Antibody
products short name :
ABHD12
products name syn :
ABHD12; abhydrolase domain containing 12; ABHD12A; BEM46L2; C20orf22; DKFZP434P106; dJ965G21.2; abhydrolase domain containing 12; ABHD12A; BEM46L2; C20orf22; DKFZP434P106; dJ965G21.2
other names :
monoacylglycerol lipase ABHD12 isoform a; Monoacylglycerol lipase ABHD12; monoacylglycerol lipase ABHD12; 2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 12; abhydrolase domain containing 12; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 12
products gene name :
ABHD12
other gene names :
ABHD12; ABHD12; PHARC; ABHD12A; BEM46L2; C20orf22; dJ965G21.2; C20orf22
uniprot entry name :
ABD12_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx. 40kDa band observed in Mouse Brain and Rat Brain lysates (calculated MW of 45.1kDa according to Human NP_001035937.1 and of 45.3kDa according to Mouse NP_077785.2). Recommended concentration: 0.3-1ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-REFLGKSEPEHQH, from the C Terminus of the protein sequence according to NP_001035937.1; NP_056415.1. Corresponding Immunizing Peptide: Catalog #MBS426264
other info2 :
Important Note: This antibody is expected to recognize isoform a (NP_001035937.1) only.
ncbi acc num :
NP_001035937.1
ncbi gb acc num :
NM_001042472.2
ncbi mol weight :
41,387 Da
ncbi pathways :
Triacylglycerol Degradation Pathway 142418
ncbi summary :
This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011]