Goat anti-PROKR2 Antibody | MyBioSource MBS421827 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-PROKR2 Antibody

catalog :

MBS421827

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421827

products type :

Antibody

products full name :

Goat anti-PROKR2 Antibody

products short name :

PROKR2

products name syn :

PROKR2; prokineticin receptor 2; GPR73L1; GPR73b; GPRg2; KAL3; PKR2; dJ680N4.3; G protein-coupled receptor 73-like 1; OTTHUMP00000030192; PROKR2 antibody; prokineticin receptor 2 antibody; GPR73L1 antibody; GPR73b antibody; GPRg2 antibody; KAL3 antibody; PKR2 antibody; dJ680N4.3 antibody; G protein-coupled receptor 73-like 1 antibody; OTTHUMP00000030192 antibody

other names :

prokineticin receptor 2; Prokineticin receptor 2; prokineticin receptor 2; prokineticin receptor 2; G-protein coupled receptor 73-like 1; G-protein coupled receptor I5E; GPR73b; GPRg2

products gene name :

PROKR2

other gene names :

PROKR2; PROKR2; HH3; KAL3; PKR2; GPRg2; GPR73b; GPR73L1; dJ680N4.3; GPR73L1; PKR2; PK-R2

uniprot entry name :

PKR2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Rat; Expected from sequence similarity: Human, Rat

sequence length :

384

sequence :

NGNTSFTPNFN

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 45kDa band observed in Human Brain (Cerebellum), Testis and Thyroid Gland and in Rat Brain, Stomach and Testis lysates (calculated MW of 44. 0kDa according to Human NP_658986.1 and 47.9kDa according to Rat NP_620434.1). Recommended concentration: 0.3-1ug/ml.

other info1 :

Immunogen: Peptide with sequence C-NGNTSFTPNFN, from the internal region of the protein sequence according to NP_658986.1. Epitope: Internal region

ncbi gi num :

21426829

ncbi acc num :

NP_658986.1

ncbi gb acc num :

NM_144773.3

ncbi mol weight :

43,996 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Other Pathway (198765); Gastrin-CREB Signalling Pathway Via PKC And MAPK (1269592); Peptide Ligand-binding Receptors Pathway (1269546); Signal Transduction Pathway (1269379); Signaling By GPCR Pathway (1269543)

ncbi summary :

Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]

uniprot summary :

PROKR2: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Defects in PROKR2 are the cause of Kallmann syndrome type 3 (KAL3); also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. KAL3 patients have variable degrees of olfactory and reproductive dysfunction, but do not show any of the occasional clinical anomalies reported in Kallmann syndrome such as renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR. Chromosomal Location of Human Ortholog: 20p12.3. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; neuropeptide Y receptor activity. Biological Process: cell surface receptor linked signal transduction; circadian rhythm; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway. Disease: Hypogonadotropic Hypogonadism 3 With Or Without Anosmia

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage