catalog number :
MBS421796
products full name :
Goat anti-KALRN Antibody
products short name :
KALRN
products name syn :
KALRN; kalirin; RhoGEF kinase; DUET; FLJ16443; HAPIP; TRAD; duo; huntingtin-associated protein interacting protein (duo); serine/threonine kinase with Dbl- and pleckstrin homology domains; Goat Anti-Kalirin (isoform 2); KALRN; kalirin, RhoGEF kinase; DUET; FLJ16443; HAPIP; TRAD; duo; huntingtin-associated protein interacting protein (duo); serine/threonine kinase with Dbl- and pleckstrin homology domains
other names :
kalirin isoform 1; Kalirin; kalirin; huntingtin-associated protein interacting protein (duo); serine/threonine kinase with Dbl- and pleckstrin homology domains; serine/threonine-protein kinase with Dbl- and pleckstrin homology domain; kalirin, RhoGEF kinase; Huntingtin-associated protein-interacting protein; Protein Duo; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
products gene name :
KALRN
other gene names :
KALRN; KALRN; DUO; CHD5; DUET; TRAD; CHDS5; HAPIP; ARHGEF24; DUET; DUO; HAPIP; TRAD
uniprot entry name :
KALRN_HUMAN
reactivity :
Human, Mouse, Rat, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Western Blot: Preliminary experiments gave an approx 49kDa band in Human, Mouse and Rat Brain lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 340kDa according to NP_001019831.2 and of 192kDa according to NP_003938.1. The 49kDa band was successfully blocked by incubation with the immunizing peptide. Peptide ELISA: antibody detection limit dilution 1:64000.
other info1 :
Epitope: N Terminus. Immunogen: Peptide with sequence DRGSFRNDGLKAS-C, from the N Terminus of the protein sequence according to NP_001019831.2; NP_003938.1; NP_008995.2. Corresponding Immunizing Peptide: Catalog #MBS425417
other info2 :
Important Note: This antibody is expected to recognize reported isoforms NP_001019831.2 and NP_003938.1.
ncbi acc num :
NP_001019831.2
ncbi gb acc num :
NM_001024660.3
ncbi mol weight :
141,164 Da
ncbi pathways :
Arf6 Downstream Pathway 138038!!Axon Guidance Pathway 105688!!Cell Death Signalling Via NRAGE, NRIF And NADE Pathway 106443!!Developmental Biology Pathway 477129!!EPH-Ephrin Signaling Pathway 1016174!!EPHB Forward Signaling Pathway 138047!!EPHB-mediated Forward Signaling Pathway 1016176!!G Alpha (12/13) Signalling Events Pathway 106041!!G Alpha (q) Signalling Events Pathway 106043!!GPCR Downstream Signaling Pathway 119548
ncbi summary :
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]