catalog number :
MBS421790
products full name :
Goat anti-GABRB2 Antibody
products short name :
GABRB2
products name syn :
GABRB2; gamma-aminobutyric acid (GABA) A receptor, beta 2; MGC119386; MGC119388; MGC119389; OTTHUMP00000160872; GABRB2 antibody; gamma-aminobutyric acid (GABA) A receptor; beta 2 antibody; MGC119386 antibody; MGC119388 antibody; MGC119389 antibody; OTTHUMP00000160872 antibody
other names :
gamma-aminobutyric acid receptor subunit beta-2 isoform 1; Gamma-aminobutyric acid receptor subunit beta-2; gamma-aminobutyric acid receptor subunit beta-2; gamma-aminobutyric acid type A receptor beta2 subunit; GABA(A) receptor subunit beta-2
products gene name :
GABRB2
other gene names :
GABRB2; GABRB2
uniprot entry name :
GBRB2_HUMAN
reactivity :
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
sequence :
HSFGRNALERHVAQ
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 4000. Western Blot: Preliminary experiments gave an approx 80kDa band in Mouse Brain lysates after 0.2 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 59.2kDa according to Human NP_068711.1 and 54.6kDa according to Mouse NP_032096.1. The 80kDa band was successfully blocked by incubation with the immunizing peptide.
other info1 :
Immunogen: Peptide with sequence C-HSFGRNALERHVAQ, from the internal region of the protein sequence according to NP_068711.1; NP_000804.1. Epitope: Internal region
other info2 :
Note: This antibody is expected to recognize both reported isoforms (NP_068711.1; NP_000804.1).
ncbi acc num :
NP_068711.1
ncbi gb acc num :
NM_021911.2
ncbi mol weight :
42,741 Da
ncbi pathways :
GABA A Receptor Activation Pathway (1268814); GABA Receptor Activation Pathway (1268813); GABAergic Synapse Pathway (377263); GABAergic Synapse Pathway (377129); Ion Channel Transport Pathway (1269950); Ligand-gated Ion Channel Transport Pathway (1269952); Morphine Addiction Pathway (552665); Morphine Addiction Pathway (554808); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462)
ncbi summary :
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]