Goat anti-TRPM8 Antibody | MyBioSource MBS421789 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-TRPM8 Antibody

catalog :

MBS421789

quantity :

0.1 mg

price :

225 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421789

products type :

Antibody

products full name :

Goat anti-TRPM8 Antibody

products short name :

TRPM8

products name syn :

transient receptor potential cation channel, subfamily M, member 8; LTRPC6; MGC2849; TRPP8; short form of the TRPM8 cationic channel; transient receptor potential subfamily M member 8; transient receptor potential cation channel; subfamily M; member 8 antibody; LTRPC6 antibody; MGC2849 antibody; TRPP8 antibody; short form of the TRPM8 cationic channel antibody; transient receptor potential subfamily M member 8 antibody

other names :

transient receptor potential cation channel subfamily M member 8; Transient receptor potential cation channel subfamily M member 8; transient receptor potential cation channel subfamily M member 8; transient receptor potential cation channel subfamily M member 8; Long transient receptor potential channel 6; LTrpC-6; LTrpC6; Transient receptor potential p8; Trp-p8

products gene name :

TRPM8

other gene names :

TRPM8; TRPM8; TRPP8; LTRPC6; LTRPC6; TRPP8; LTrpC-6; LTrpC6; Trp-p8

uniprot entry name :

TRPM8_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Expected from sequence similarity: Human, Mouse, Rat

sequence length :

1104

sequence :

TSEQDKDNWNGQLK

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Preliminary experiments gave an approx 28kDa band in lysates of cell line NIH3T3 after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 128kDa according to NP_076985.4. The 28kDa band was successfully blocked by incubation with the immunizing peptide.

other info1 :

Immunogen: Peptide with sequence C-TSEQDKDNWNGQLK, from the internal region of the protein sequence according to NP_076985.4. Epitope: Internal region

ncbi gi num :

109689695

ncbi acc num :

NP_076985.4

ncbi gb acc num :

NM_024080.4

ncbi mol weight :

79,096 Da

ncbi pathways :

Inflammatory Mediator Regulation Of TRP Channels Pathway (948277); Inflammatory Mediator Regulation Of TRP Channels Pathway (948307); Ion Channel Transport Pathway (1269950); Stimuli-sensing Channels Pathway (1269953); TRP Channels Pathway (1269954); Transmembrane Transport Of Small Molecules Pathway (1269903)

uniprot summary :

TRPM8: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q37.1. Cellular Component: endoplasmic reticulum membrane; external side of plasma membrane; integral to membrane; lipid raft; plasma membrane. Molecular Function: calcium channel activity; protein binding; protein homodimerization activity. Biological Process: cellular calcium ion homeostasis; detection of temperature stimulus; protein homotetramerization; response to cold; thermoception

size1 :

0.1 mg

price1 :

225 USD

more info or order :

MyBioSource product webpage