Goat anti-ETV1 Antibody | MyBioSource MBS421744 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-ETV1 Antibody

catalog :

MBS421744

quantity :

0.1 mg

price :

225 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421744

products type :

Antibody

products full name :

Goat anti-ETV1 Antibody

products short name :

ETV1

products name syn :

ETV1; ets variant gene 1; HGNC: 3490; DKFZp781L0674; ER81; MGC104699; MGC120533; MGC120534; ets variant 1; ETV1 antibody; ets variant gene 1 antibody; HGNC: 3490 antibody; DKFZp781L0674 antibody; ER81 antibody; MGC104699 antibody; MGC120533 antibody; MGC120534 antibody; ets variant 1 antibody

other names :

ETS translocation variant 1 isoform a; ETS translocation variant 1; ETS translocation variant 1; ETS variant 1; Ets-related protein 81

products gene name :

ETV1

other gene names :

ETV1; ETV1; ER81; ER81

uniprot entry name :

ETV1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Expected from sequence similarity: Human, Mouse, Rat, Dog

sequence length :

477

sequence :

PLKIKKEPHSPCSE

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Preliminary experiments in lysates in cell line A431 gave no specific signal but low background (at antibody concentration up to 1ug/ml).

other info1 :

Immunogen: Peptide with sequence PLKIKKEPHSPCSE, from the internal region of the protein sequence according to NP_004947.2; NP_001156619.1; NP_001156620.1; NP_001156621.1; NP_001156622.1; NP_001156623.1; NP_001156624.1. Epitope: Internal region

other info2 :

Note: This antidbody is expected to recognise all reported isoforms. Variants (NP_001156620.1; NP_001156621.1) encode the same isoform.

ncbi gi num :

31742534

ncbi acc num :

NP_004947.2

ncbi gb acc num :

NM_004956.4

ncbi mol weight :

50,217 Da

ncbi pathways :

Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987); P38 Signaling Mediated By MAPKAP Kinases Pathway (138078)

ncbi summary :

This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

uniprot summary :

ETV1: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. Defects in ETV1 are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1. Belongs to the ETS family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor; Oncoprotein. Chromosomal Location of Human Ortholog: 7p21.3. Cellular Component: nucleus. Molecular Function: protein binding; transcription factor activity. Biological Process: axon guidance; mechanosensory behavior; muscle development; peripheral nervous system neuron development; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

size1 :

0.1 mg

price1 :

225 USD

more info or order :

MyBioSource product webpage