Goat anti-CHRNB2 Antibody | MyBioSource MBS421737 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-CHRNB2 Antibody

catalog :

MBS421737

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421737

products type :

Antibody

products full name :

Goat anti-CHRNB2 Antibody

products short name :

CHRNB2

products name syn :

CHRNB2; cholinergic receptor, nicotinic, beta 2 (neuronal); EFNL3; nAChRB2; cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal); neuronal nicotinic acetylcholine receptor beta 2; CHRNB2 antibody; cholinergic receptor; nicotinic; beta 2 (neuronal) antibody; EFNL3 antibody; nAChRB2 antibody; cholinergic receptor; nicotinic; beta polypeptide 2 (neuronal) antibody; neuronal nicotinic acetylcholine receptor beta 2 antibody

other names :

neuronal acetylcholine receptor subunit beta-2; Neuronal acetylcholine receptor subunit beta-2; neuronal acetylcholine receptor subunit beta-2; cholinergic receptor nicotinic beta 2 subunit

products gene name :

CHRNB2

other gene names :

CHRNB2; CHRNB2; EFNL3; nAChRB2

uniprot entry name :

ACHB2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

sequence length :

502

sequence :

QPRHHCARQRLR

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: approx. 48 kDa band observed in Human Brain (Cerebellum, Cerebral Cortex) lysates (calculated MW of 57. 0 kDa according to NP_000739.1). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence QPRHHCARQRLR, from the internal region of the protein sequence according to NP_000739.1. Epitope: Internal region

ncbi gi num :

4502833

ncbi acc num :

NP_000739.1

ncbi gb acc num :

NM_000748.2

ncbi mol weight :

57,019 Da

ncbi pathways :

Acetylcholine Binding And Downstream Events Pathway (1268787); Activation Of Nicotinic Acetylcholine Receptors Pathway (1268788); Cholinergic Synapse Pathway (217716); Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway (1268790); Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway (1268793); Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway (1268791); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Neuronal System Pathway (1268763); Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway (1268786)

ncbi summary :

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]

uniprot summary :

nAChRB2: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRNB2 are the cause of nocturnal frontal lobe epilepsy type 3 (ENFL3). ENFL3 is an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 2/CHRNB2 sub-subfamily. Protein type: Channel, ligand-gated; Membrane protein, integral; Channel, cation; Membrane protein, multi-pass; Receptor, misc. Chromosomal Location of Human Ortholog: 1q21.3. Cellular Component: cell junction; external side of plasma membrane; integral to membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; postsynaptic membrane. Molecular Function: acetylcholine binding; acetylcholine receptor activity; drug binding; ligand-gated ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity; protein binding; protein heterodimerization activity. Biological Process: associative learning; B cell activation; behavioral response to nicotine; calcium ion transport; central nervous system projection neuron axonogenesis; cognition; conditioned taste aversion; ion transport; lateral geniculate nucleus development; learning; locomotory behavior; membrane depolarization; memory; negative regulation of action potential; neurological system process; neuromuscular synaptic transmission; optic nerve morphogenesis; positive regulation of B cell proliferation; positive regulation of dopamine secretion; positive regulation of synaptic transmission, dopaminergic; protein heterooligomerization; regulation of action potential; regulation of circadian sleep/wake cycle, non-REM sleep; regulation of circadian sleep/wake cycle, REM sleep; regulation of dendrite morphogenesis; regulation of dopamine metabolic process; regulation of dopamine secretion; regulation of synaptic transmission, dopaminergic; regulation of synaptogenesis; response to cocaine; response to ethanol; response to hypoxia; response to nicotine; sensory perception of pain; sensory perception of sound; signal transduction; smooth muscle contraction; social behavior; synaptic transmission involved in micturition; synaptic transmission, cholinergic; vestibulocochlear nerve development; visual learning; visual perception. Disease: Epilepsy, Nocturnal Frontal Lobe, 3

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage