Goat anti-Tyrosine Hydroxylase Antibody | MyBioSource MBS421729 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Tyrosine Hydroxylase Antibody

catalog :

MBS421729

quantity :

0.1 mg

price :

305 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, rat, dog

application :

immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

MBS421729 immunostaining of dopaminergic neurons in cryosection of an immersion-fixed (4% PFA) human hypothalamus. HRP-staining with Ni-DAB, after Biotin-SP-anti-goat (IgG) method. Data obtained by Drs. Éva Rumpler and Erik Hrabovszky, Inst, Exp, Med, Budapest, Hungary.

product information

catalog number :

MBS421729

products type :

Antibody

products full name :

Goat anti-Tyrosine Hydroxylase Antibody

products short name :

[Tyrosine Hydroxylase]

products name syn :

[TH; tyrosine hydroxylase; HGNC: 11782; TYH; DYT14; DYT5b; dystonia 14; tyrosine 3-monooxygenase]

other names :

[tyrosine 3-monooxygenase isoform a; Tyrosine 3-monooxygenase; tyrosine 3-monooxygenase; tyrosine hydroxylase; Tyrosine 3-hydroxylase; TH]

products gene name :

[TH]

other gene names :

[TH; TH; TYH; DYT14; DYT5b; TYH; TH]

uniprot entry name :

TY3H_HUMAN

clonality :

polyclonal

host :

goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Rat, Dog

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

storage stability :

Aliquot and store at -20°C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Immunohistochemistry: Cryosections of Human Hypothalamus. Recommended dilution range between 1:1000 and 1:10,0000.

image1 heading :

Testing Data

other info1 :

Immunogen: Peptide with sequence C-VQDELDTLAHAL, from the C Terminus of the protein sequence according to NP_954986.2; NP_000351.2; NP_954987.2.

other info2 :

Note: This antibody is expected to recognize all three reported isoforms (as represented by NP_954986.2; NP_000351.2; NP_954987.2).

ncbi gi num :

88900501

ncbi acc num :

NP_954986.2

ncbi gb acc num :

NM_199292.2

ncbi pathways :

ATF-2 Transcription Factor Network Pathway (138006); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Alpha-synuclein Signaling Pathway (137913); Amine-derived Hormones Pathway (1270175); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Biogenic Amine Synthesis Pathway (198793); Catecholamine Biosynthesis Pathway (1270176); Catecholamine Biosynthesis, Tyrosine = Dopamine = Noradrenaline = Adrenaline Pathway (413357)

ncbi summary :

The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

TH: an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described. Protein type: Endoplasmic reticulum; Oxidoreductase; Vesicle; Amino Acid Metabolism - tyrosine; Mitochondrial; EC 1.14.16.2. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; dendrite; internal side of plasma membrane; melanosome membrane; mitochondrion; neuron projection; nucleus; perikaryon; smooth endoplasmic reticulum; synaptic vesicle; terminal button. Molecular Function: amino acid binding; dopamine binding; enzyme binding; ferric iron binding; ferrous iron binding; oxygen binding; protein binding; protein domain specific binding; tyrosine 3-monooxygenase activity. Biological Process: anatomical structure morphogenesis; catecholamine biosynthetic process; cerebral cortex development; circadian sleep/wake cycle; dopamine biosynthetic process; dopamine biosynthetic process from tyrosine; eating behavior; embryonic camera-type eye morphogenesis; epinephrine biosynthetic process; eye photoreceptor cell development; fatty acid metabolic process; glycoside metabolic process; heart development; heart morphogenesis; isoquinoline alkaloid metabolic process; learning; locomotory behavior; mating behavior; memory; multicellular organismal aging; neurotransmitter biosynthetic process; norepinephrine biosynthetic process; organ morphogenesis; phthalate metabolic process; phytoalexin metabolic process; pigmentation; regulation of heart contraction; response to activity; response to amphetamine; response to corticosterone stimulus; response to electrical stimulus; response to estradiol stimulus; response to ethanol; response to ether; response to herbicide; response to hypoxia; response to light stimulus; response to lipopolysaccharide; response to nutrient levels; response to peptide hormone stimulus; response to pyrethroid; response to salt stress; response to water deprivation; response to zinc ion; sensory perception of sound; social behavior; sphingolipid metabolic process; synaptic transmission, dopaminergic; synaptic vesicle amine transport; terpene metabolic process; visual perception. Disease: Segawa Syndrome, Autosomal Recessive

size1 :

0.1 mg

price1 :

305 USD

more info or order :

MyBioSource product webpage