antibody

Goat anti-IKAROS / IKZF1 Antibody

MBS421728

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, dog, cow

western blot, immunohistochemistry, enzyme immunoassay

Antibody

Goat anti-IKAROS / IKZF1 Antibody

IKAROS/IKZF1

IKZF1; IKAROS family zinc finger 1 (Ikaros); Hs.54452; IK1; IKAROS; LYF1; PRO0758; ZNFN1A1; hIk-1; CLL-associated antigen KW-6; Ikaros (zinc finger protein); zinc finger protein; subfamily 1A; 1 (Ikaros); lymphoid transcription factor LyF-1; Goat Anti-IKZF1 / IKAROS; IKZF1; IKAROS family zinc finger 1 (Ikaros); Hs.54452; IK1; IKAROS; LYF1; PRO0758; ZNFN1A1; hIk-1; CLL-associated antigen KW-6; Ikaros (zinc finger protein); zinc finger protein, subfamily 1A, 1 (Ikaros); lymphoid transcription factor LyF-1

DNA-binding protein Ikaros isoform 1; DNA-binding protein Ikaros; DNA-binding protein Ikaros; CLL-associated antigen KW-6; ikaros family zinc finger protein 1; lymphoid transcription factor LyF-1; protein phosphatase 1, regulatory subunit 92; zinc finger protein, subfamily 1A, 1 (Ikaros); IKAROS family zinc finger 1 (Ikaros); Ikaros family zinc finger protein 1; Lymphoid transcription factor LyF-1

IKZF1

IKZF1; IKZF1; IK1; LYF1; LyF-1; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452; IK1; IKAROS; LYF1; ZNFN1A1

IKZF1_HUMAN

Polyclonal

Goat

Human, Dog, Cow

519

DTPYDSSASYEKEN

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry: In paraffin embedded Human Tonsil shows textured staining in some nuclei of the lymphoid tissue. Recommended concentration, 2.5-3.8ug/ml. Western Blot: Approx 65kDa band observed in lysates of cell line MOLT4 (calculated MW of 57.5kDa according to NP_006051.1). Recommended concentration: 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:1000.

Epitope: Internal Region. Immunogen: Peptide with sequence C-DTPYDSSASYEKEN, from the internal region of the protein sequence according to NP_006051.1.

Corresponding Immunizing Peptide: Catalog #MBS426326

5174501

NP_006051.1

NM_006060.5

24,470 Da

Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]

0.1 mg

290 USD