catalog number :
MBS421693
products full name :
Goat anti-PACAP Antibody
products short name :
PACAP
products name syn :
ADCYAP1; adenylate cyclase activating polypeptide 1 (pituitary); MGC126852; PACAP; OTTHUMP00000162201; adenylate cyclase activating polypeptide; ADCYAP1 antibody; adenylate cyclase activating polypeptide 1 (pituitary) antibody; MGC126852 antibody; PACAP antibody; OTTHUMP00000162201 antibody; adenylate cyclase activating polypeptide antibody
other names :
pituitary adenylate cyclase-activating polypeptide preproprotein; Pituitary adenylate cyclase-activating polypeptide; pituitary adenylate cyclase-activating polypeptide; adenylate cyclase activating polypeptide 1; PACAP-related peptideAlternative name(s):PRP-48
products gene name :
ADCYAP1
products gene name syn :
PACAP
other gene names :
ADCYAP1; ADCYAP1; PACAP; PACAP; PACAP-27; PACAP27; PACAP-38; PACAP38
uniprot entry name :
PACA_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Pig
sequence :
GKRYKQRVKNKGRR
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 2000. Western Blot: Approx 25kDa band observed in Human Brain (Cerebral Cortex, Cerebellum and Hippocampus) lysates (calculated MW of 18.8kDa according to NP_001108.2). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 1-3ug/ml.
other info1 :
Immunogen: Peptide with sequence C-GKRYKQRVKNKGRR, from the C Terminus of the protein sequence according to NP_001108.2. Epitope: C Terminus
other info2 :
Note: Reported variants represent identical protein: NP_001093203.1, NP_001108.2.
ncbi acc num :
NP_001108.2
ncbi gb acc num :
NM_001117.4
ncbi mol weight :
18,835 Da
ncbi pathways :
Activation Of TRKA Receptors Pathway (1269461); Class B/2 (Secretin Family Receptors) Pathway (1269570); G Alpha (s) Signalling Events Pathway (1269575); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); Glucagon-type Ligand Receptors Pathway (1269572); Insulin Secretion Pathway (777534); NGF Signalling Via TRKA From The Plasma Membrane Pathway (1269460); NGF-independant TRKA Activation Pathway (1269463); Renin Secretion Pathway (1222951)
ncbi summary :
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]