antibody

Goat anti-LMP7 Antibody

MBS421670

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

western blot, enzyme immunoassay

Antibody

Goat anti-LMP7 Antibody

LMP7

PSMB8; proteasome (prosome; macropain) subunit; beta type; 8 (large multifunctional peptidase 7); D6S216; D6S216E; LMP7; MGC1491; PSMB5i; RING10; beta5i; OTTHUMP00000029420; OTTHUMP00000029421; OTTHUMP00000062981; low molecular weight protein 7; macropain subunit C13; multicatalytic endopeptidase complex subunit C13; protease component C13; proteasome (prosome; macropain) subunit beta type 8 (large multifunctional protease 7); proteasome beta 8 subunit; proteasome catalytic subunit 3i; proteasome subunit Y2; proteasome subunit beta 5i; proteasome-related gene 7; PSMB8; proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7); D6S216; D6S216E; LMP7; MGC1491; PSMB5i; RING10; beta5i; OTTHUMP00000029420; OTTHUMP00000029421; OTTHUMP00000062981; low molecular weight protein 7; macropain subunit C13; multicatalytic endopeptidase complex subunit C13; protease component C13; proteasome (prosome, macropain) subunit beta type 8 (large multifunctional protease 7); proteasome beta 8 subunit; proteasome catalytic subunit 3i; proteasome subunit Y2; proteasome subunit beta 5i; proteasome-related gene 7

proteasome subunit beta type-8 isoform E1 proprotein; Proteasome subunit beta type-8; proteasome subunit beta type-8; macropain subunit C13; proteasome subunit Y2; protease component C13; proteasome component C13; proteasome-related gene 7; proteasome subunit beta 5i; low molecular mass protein 7; low molecular weight protein 7; proteasome catalytic subunit 3i; large multifunctional peptidase 7; really interesting new gene 10 protein; multicatalytic endopeptidase complex subunit C13; proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7); proteasome (prosome, macropain) subunit, beta type, 8; Low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; Proteasome component C13; Proteasome subunit beta-5i; Really interesting new gene 10 protein

PSMB8

PSMB8; PSMB8; JMP; ALDD; LMP7; NKJO; D6S216; PSMB5i; RING10; D6S216E; LMP7; PSMB5i; RING10; Y2

PSB8_HUMAN

Polyclonal

Goat

Human, Mouse, Rat, Dog, Pig, Cow

272

DVSDLLHQYREANQ

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Western Blot: Approx 22kDa band observed in Human Liver, Lung and Lymph Node lysates (calculated MW of 29.8kDa according to precursor NP_004150.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Schwarz et al, J Immunol. 2000 Jul 15;165(2):768-78. PMID: 10878350. Recommended concentration: 0.01-0.03ug/ml. Peptide ELISA: antibody detection limit dilution 1:8000.

Epitope: C Terminus. Immunogen: Peptide with sequence C-DVSDLLHQYREANQ, from the C Terminus of the protein sequence according to NP_004150.1; NP_683720.2. Corresponding Immunizing Peptide: Catalog #MBS425809

Important Note: This antibody is expected to recognize both reported isoforms (NP_004150.1; NP_683720.2).

4758970

NP_004150.1

NM_004159.4

29,770 Da

AMER1 Mutants Destabilize The Destruction Complex Pathway 1016198!!APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway 1016193!!APC Truncation Mutants Have Impaired AXIN Binding Pathway 1016194!!APC/C-mediated Degradation Of Cell Cycle Proteins Pathway 105825!!APC/C:Cdc20 Mediated Degradation Of Securin Pathway 105833!!APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway 105831!!APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway 105835!!AUF1 (hnRNP D0) Destabilizes MRNA Pathway 187212!!AXIN Missense Mutants Destabilize The Destruction Complex Pathway 1016197!!AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway 1016195

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008]

0.1 mg

290 USD