antibody

Goat anti-P2RX7/P2X7 receptor Antibody

MBS421665

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, dog

western blot, immunohistochemistry, enzyme immunoassay

Antibody

Goat anti-P2RX7/P2X7 receptor Antibody

P2RX7/P2X7 receptor

P2RX7; purinergic receptor P2X, ligand-gated ion channel, 7; MGC20089; P2X7; ATP receptor; P2X purinoceptor 7; P2X7 receptor; P2Z receptor; purinergic receptor P2X7; P2RX7 antibody; purinergic receptor P2X; ligand-gated ion channel; 7 antibody; MGC20089 antibody; P2X7 antibody; ATP receptor antibody; P2X purinoceptor 7 antibody; P2X7 receptor antibody; P2Z receptor antibody; purinergic receptor P2X7 antibody; P2RX7 / P2X7 receptor

P2X purinoceptor 7; P2X purinoceptor 7; P2X purinoceptor 7; purinergic receptor P2X 7; ATP receptor; P2Z receptor; Purinergic receptor

P2RX7

P2X7

P2RX7; P2RX7; P2X7; P2X7

P2RX7_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog

595

YETNKVTRIQSMNY

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Peptide ELISA: Antibody detection limit dilution 1: 16000. Immunohistochemistry: In paraffin embedded Human Brain Cortex shows membranous staining of cell bodies and processes. Recommended concentration, 3-6ug/ml. Western Blot: Approx 37kDa and 70kDa band observed in Human Brain (Frontal Cortex) lysates (calculated MW of 68.6kDa according to NP_002553.2). Recommended concentration: 1-3ug/ml.

Immunogen: Peptide with sequence YETNKVTRIQSMNY-C, from the N Terminus of the protein sequence according to NP_002553.2. Epitope: N Terminus

29294631

NP_002553.2

NM_002562.4

58,239 Da

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Elevation Of Cytosolic Ca2+ Levels Pathway (1269346); Hemostasis Pathway (1269340); Immune System Pathway (1269170); Inflammasomes Pathway (1269253); Innate Immune System Pathway (1269203); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways (1269251)

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

P2X7: a receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis by macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Alternatively spliced variants encoding different isoforms have been identified. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. Phosphorylation results in its inactivation. Protein type: Membrane protein, multi-pass; Receptor, misc.; Channel, ligand-gated; Membrane protein, integral. Chromosomal Location of Human Ortholog: 12q24. Cellular Component: cell soma; cytoplasm; cytosol; external side of plasma membrane; integral to nuclear inner membrane; integral to plasma membrane; intercellular junction; membrane; neuromuscular junction; plasma membrane. Molecular Function: ATP binding; ATP-gated cation channel activity; lipopolysaccharide binding; protein binding; protein homodimerization activity; purinergic nucleotide receptor activity; receptor binding. Biological Process: activation of MAPK activity; bleb formation; blood coagulation; cell morphogenesis; cell surface receptor linked signal transduction; cellular response to extracellular stimulus; ceramide biosynthetic process; collagen metabolic process; cytolysis; defense response to Gram-positive bacterium; homeostasis of number of cells within a tissue; inflammatory response; membrane budding; membrane depolarization; membrane protein ectodomain proteolysis; mitochondrion organization and biogenesis; multicellular organismal protein catabolic process; NAD transport; negative regulation of bone resorption; negative regulation of cell volume; negative regulation of MAPKKK cascade; phagolysosome formation; phospholipid scrambling; phospholipid transfer to membrane; phospholipid translocation; pore complex biogenesis; positive regulation of bone mineralization; positive regulation of cytolysis; positive regulation of cytoskeleton organization and biogenesis; positive regulation of gamma-aminobutyric acid secretion; positive regulation of glutamate secretion; positive regulation of glycolysis; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of mitochondrial depolarization; positive regulation of prostaglandin secretion; positive regulation of T cell mediated cytotoxicity; protein amino acid phosphorylation; protein oligomerization; protein processing; regulation of killing of cells of another organism; regulation of sodium ion transport; release of sequestered calcium ion into cytosol; response to ATP; response to calcium ion; response to drug; response to electrical stimulus; response to lipopolysaccharide; response to mechanical stimulus; response to zinc ion; sensory perception of pain; skeletal morphogenesis; synaptic vesicle exocytosis; T cell homeostasis; T cell proliferation. Disease: Leukemia, Chronic Lymphocytic

0.1 mg

300 USD