catalog number :
MBS421654
products full name :
Goat anti-ORAI1 / CRACM1 Antibody
products short name :
ORAI1/CRACM1
products name syn :
ORAI1; CRACM1; ORAI calcium release-activated calcium modulator 1; FLJ14466; ORAT1; TMEM142A; calcium release-activated calcium channel protein 1; calcium release-activated calcium modulator 1; transmembrane protein 142A; ORAI1; CRACM1; ORAI calcium release-activated calcium modulator 1; FLJ14466; ORAT1; TMEM142A; calcium release-activated calcium channel protein 1; calcium release-activated calcium modulator 1; transmembrane protein 142A
other names :
calcium release-activated calcium channel protein 1; Calcium release-activated calcium channel protein 1; calcium release-activated calcium channel protein 1; protein orai-1; transmembrane protein 142A; calcium release-activated calcium modulator 1; ORAI calcium release-activated calcium modulator 1; Protein orai-1; Transmembrane protein 142A
products gene name :
ORAI1
other gene names :
ORAI1; ORAI1; IMD9; TAM2; ORAT1; CRACM1; TMEM142A; CRACM1; TMEM142A
uniprot entry name :
CRCM1_HUMAN
reactivity :
Human, Dog, Pig
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx. 50-55kDa band observed in Human Liver and Human Placenta lysates (calculated MW of 32.7kDa according to NP_116179.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Li et al, J Biol Chem. 2007 Oct 5;282(40):29448-56.; PMID: 17702753). Recommended concentration: 0.03-0.1ug/ml. Peptide ELISA: antibody detection limit dilution 1:64000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-KKQPGQPRPTSKP, from the internal region of the protein sequence according to NP_116179.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS426284
ncbi acc num :
NP_116179.2
ncbi gb acc num :
NM_032790.3
ncbi mol weight :
25,337 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway 576249!!Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!Elevation Of Cytosolic Ca2+ Levels Pathway 106047!!Hemostasis Pathway 106028!!Immune System Pathway 106386!!Platelet Activation Pathway 952858!!Platelet Calcium Homeostasis Pathway 187202!!Platelet Homeostasis Pathway 187198
ncbi summary :
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]