catalog number :
MBS421649
products full name :
Goat anti-PBR (mouse) Antibody
products short name :
PBR
products name syn :
PBR; Tspo; translocator protein; Bzrp; IBP; benzodiazepine receptor, peripheral; isoquinoline-binding protein; peripheral benzodiazepine receptor; PBR antibody; Tspo antibody; translocator protein antibody; Bzrp antibody; IBP antibody; benzodiazepine receptor; peripheral antibody; isoquinoline-binding protein antibody; peripheral benzodiazepine receptor antibody; PBR (mouse)
other names :
translocator protein; Translocator protein; translocator protein; translocator protein; Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR
products gene name :
Tspo
products gene name syn :
PBR
other gene names :
Tspo; Tspo; IBP; PBR; Bzrp; Tspo1; Bzrp; Mbr; PBR
uniprot entry name :
TSPO_MOUSE
reactivity :
Tested: Mouse; Expected from sequence similarity: Mouse, Rat
sequence :
RDNSGRRGGSRLPE
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx.18kDa band observed in Mouse Kidney and approx.17kDa doublet observed in Mouse Spleen lysates (calculated MW of 18.8kDa according to NP_033905.3). Recommended concentration: 0.3-1ug/ml.
other info1 :
Immunogen: Peptide with sequence C-RDNSGRRGGSRLPE, from the C Terminus of the protein sequence according to NP_033905.3. Epitope: C Terminus
ncbi acc num :
NP_033905.3
ncbi gb acc num :
NM_009775.4
ncbi mol weight :
18,841 Da
ncbi pathways :
HTLV-I Infection Pathway (373903); HTLV-I Infection Pathway (373889); Neuroactive Ligand-receptor Interaction Pathway (83250); Neuroactive Ligand-receptor Interaction Pathway (462)
uniprot summary :
TSPO: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells. Belongs to the TspO/BZRP family. Interacts with BZRAP1. May interact with STAR. Interacts with MOST-1. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Mitochondrial; Apoptosis; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Cellular Component: cytoplasm; integral to membrane; intracellular membrane-bound organelle; membrane; mitochondrial outer membrane; mitochondrion; nuclear membrane. Molecular Function: androgen binding; benzodiazepine receptor activity. Biological Process: behavioral response to pain; chloride transport; glial cell migration; ion transport; lipid transport; negative regulation of nitric oxide biosynthetic process; negative regulation of protein ubiquitination; negative regulation of tumor necrosis factor production; positive regulation of apoptosis; positive regulation of calcium ion transport; positive regulation of mitochondrial depolarization; regulation of steroid biosynthetic process; steroid biosynthetic process; transport