catalog number :
MBS421640
products full name :
Goat anti-FTH1 Antibody
products short name :
FTH1
products name syn :
FTH1; ferritin, heavy polypeptide 1; FHC; FTH; FTHL6; MGC104426; PIG15; PLIF; apoferritin; placenta immunoregulatory factor; proliferation-inducing protein 15; FTH1 antibody; ferritin; heavy polypeptide 1 antibody; FHC antibody; FTH antibody; FTHL6 antibody; MGC104426 antibody; PIG15 antibody; PLIF antibody; apoferritin antibody; placenta immunoregulatory factor antibody; proliferation-inducing protein 15 antibody
other names :
ferritin heavy chain; Ferritin heavy chain; ferritin heavy chain; ferritin, heavy polypeptide 1; Cell proliferation-inducing gene 15 protein
products gene name :
FTH1
other gene names :
FTH1; FTH1; FHC; FTH; HFE5; PLIF; FTHL6; PIG15; FTH; FTHL6; Ferritin H subunit
uniprot entry name :
FRIH_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human, Dog
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 4000. Immunohistochemistry: In paraffin embedded Human Kidney shows very strong staining of PCT cytoplasm, but not in DCT cytoplasm. Data obtained from a previous batch (different goat). Western Blot: Approx.22kDa band observed in Human Brain (Cerebellum), Liver and Placenta lysates (calculated MW of 21.2kDa according to NP_002023.2). Recommended concentration: 0. 03-0.1ug/ml.
other info1 :
Immunogen: Peptide with sequence C-DKHTLGDSDNES, from the C Terminus of the protein sequence according to NP_002023.2. Epitope: C Terminus
ncbi acc num :
NP_002023.2
ncbi gb acc num :
NM_002032.2
ncbi mol weight :
21,226 Da
ncbi pathways :
Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1269897); Clathrin Derived Vesicle Budding Pathway (1269881); Golgi Associated Vesicle Biogenesis Pathway (1269882); Iron Metabolism In Placenta Pathway (672461); Iron Uptake And Transport Pathway (1269948); Membrane Trafficking Pathway (1269877); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Scavenging By Class A Receptors Pathway (1269899); Transmembrane Transport Of Small Molecules Pathway (1269903)
ncbi summary :
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]