catalog number :
MBS421636
products full name :
Goat anti-ALS Antibody
products short name :
ALS
products name syn :
IGFALS; insulin-like growth factor binding protein; acid labile subunit; ALS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN COMPLEX ACID LABILE CHAIN; IGFALS; insulin-like growth factor binding protein, acid labile subunit; ALS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN COMPLEX ACID LABILE CHAIN
other names :
insulin-like growth factor-binding protein complex acid labile subunit isoform 2; Insulin-like growth factor-binding protein complex acid labile subunit; insulin-like growth factor-binding protein complex acid labile subunit; insulin-like growth factor binding protein complex acid labile chain; insulin-like growth factor binding protein, acid labile subunit
products gene name :
IGFALS
other gene names :
IGFALS; IGFALS; ALS; ACLSD; ALS; ALS
uniprot entry name :
ALS_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow, Pig
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Western Blot: Preliminary experiments gave an approx 45kDa band in lysates of cell line HepG2 after 2ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 66.0kDa according to NP_004961.1. The 45kDa band was successfully blocked by incubation with the immunizing peptide. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-GLDLRDLSEAH, from the C Terminus of the protein sequence according to NP_004961.1.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425019
ncbi acc num :
NP_004961.1
ncbi gb acc num :
NM_004970.2
ncbi mol weight :
70,236 Da
ncbi pathways :
Metabolism Of Proteins Pathway 106230!!Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway 105908
ncbi summary :
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]