product summary
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company name :
MyBioSource
product type :
antibody
product name :
Goat anti-LASS3/CerS3 Antibody
catalog :
MBS421629
quantity :
0.1 mg
price :
300 USD
clonality :
polyclonal
host :
goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, enzyme immunoassay
more info or order :
product information
catalog number :
MBS421629
products type :
Antibody
products full name :
Goat anti-LASS3/CerS3 Antibody
products short name :
LASS3/CerS3
products name syn :
LASS3; CerS3; LAG1 homolog, ceramide synthase 3; MGC27091; LAG1 longevity assurance homolog 3; LASS3 antibody; CerS3 antibody; LAG1 homolog; ceramide synthase 3 antibody; MGC27091 antibody; LAG1 longevity assurance homolog 3 antibody; LASS3 / CerS3
other names :
ceramide synthase 3 isoform 2; Ceramide synthase 3; ceramide synthase 3; ceramide synthase 3; Dihydroceramide synthase 3; LAG1 longevity assurance homolog 3
products gene name :
LASS3
products gene name syn :
CerS3
other gene names :
CERS3; CERS3; ARCI9; LASS3; LASS3; CerS3
uniprot entry name :
CERS3_HUMAN
clonality :
Polyclonal
host :
Goat
reactivity :
Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat
sequence length :
383
sequence :
RAERHLIPNGQHGH
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: approx. 45 kDa band observed in Rat Testis lysates (calculated MW of 46.3 kDa according to Human NP_849164.2 and of 47.2 kDa according to Rat NP_001121033.1). Recommended concentration: 2-3ug/ml.
other info1 :
Immunogen: Peptide with sequence C-RAERHLIPNGQHGH, from the C Terminus of the protein sequence according to NP_849164.2. Epitope: C Terminus
ncbi gi num :
116235446
ncbi acc num :
NP_849164.2
ncbi gb acc num :
NM_178842.4
ncbi mol weight :
46,316 Da
ncbi pathways :
Ceramide Biosynthesis Pathway (524496); Ceramide Biosynthesis Pathway (468287); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Sphingolipid Metabolism Pathway (760636); Sphingolipid De Novo Biosynthesis Pathway (1270098); Sphingolipid Metabolism Pathway (82994); Sphingolipid Metabolism Pathway (1270097); Sphingolipid Metabolism Pathway (369)
ncbi summary :
This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
uniprot summary :
Lass3: Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs. It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation. Protein type: DNA-binding; Membrane protein, multi-pass; Membrane protein, integral; EC 2.3.1.24. Chromosomal Location of Human Ortholog: 15q26.3. Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear membrane. Molecular Function: DNA binding; sphingosine N-acyltransferase activity. Biological Process: ceramide biosynthetic process; keratinocyte differentiation; sphingolipid biosynthetic process. Disease: Ichthyosis, Congenital, Autosomal Recessive 9
size1 :
0.1 mg
price1 :
300 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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