Goat anti-GRIA4 Antibody | MyBioSource MBS421628 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-GRIA4 Antibody

catalog :

MBS421628

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421628

products type :

Antibody

products full name :

Goat anti-GRIA4 Antibody

products short name :

GRIA4

products name syn :

GRIA4; glutamate receptor, ionotrophic, AMPA 4; GLUR4; GLUR4C; GLURD; AMPA-selective glutamate receptor 4; GRIA4 antibody; glutamate receptor; ionotrophic; AMPA 4 antibody; GLUR4 antibody; GLUR4C antibody; GLURD antibody; AMPA-selective glutamate receptor 4 antibody

other names :

glutamate receptor 4 isoform 1; Glutamate receptor 4; glutamate receptor 4; glutamate ionotropic receptor AMPA type subunit 4; AMPA-selective glutamate receptor 4; GluR-D; Glutamate receptor ionotropic, AMPA 4; GluA4

products gene name :

GRIA4

other gene names :

GRIA4; GRIA4; GLUR4; GLURD; GluA4; GLUR4C; GLUR4; GluR-4; GluR4; GluA4

uniprot entry name :

GRIA4_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow

sequence length :

902

sequence :

KKLDQREYPGSETP

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 128000. Immunohistochemistry: In paraffin embedded Human Cortex shows cytoplasm staining of neuronal cells. Recommended concentration, 5-10ug/ml. Western Blot: Approx.90 kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 99.2 kDa according to NP_001070711.1). Recommended concentration: 0.3-1ug/ml.

other info1 :

Immunogen: Peptide with sequence C-KKLDQREYPGSETP, from the internal region of the protein sequence according to NP_000820.3; NP_001070711.1; NP_001070712.1. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognize all reported isforms (NP_000820.3; NP_001070711.1; NP_001070712.1). Reported variants NP_001070712.1 and NP_001106283.1 represent identical protein.

ncbi gi num :

164419734

ncbi acc num :

NP_000820.3

ncbi gb acc num :

NM_000829.3

ncbi mol weight :

49,146 Da

ncbi pathways :

Activation Of AMPA Receptors Pathway (1268797); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (1268798); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Circadian Entrainment Pathway (698773); Circadian Entrainment Pathway (699872); Dopaminergic Synapse Pathway (469199); Dopaminergic Synapse Pathway (469185); Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway (1268794); Glutamatergic Synapse Pathway (213818)

ncbi summary :

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA- R- G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]

uniprot summary :

GluR4: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) glutamate kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11q22. Cellular Component: cell junction; cell soma; dendrite; plasma membrane; postsynaptic membrane; terminal button. Molecular Function: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; excitatory extracellular ligand-gated ion channel activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity. Biological Process: glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; synaptic transmission; transport

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage