catalog number :
MBS421614
products full name :
Goat anti-RASSF6 Antibody
products short name :
RASSF6
products name syn :
RASSF6; Ras association (RalGDS/AF-6) domain family 6; DKFZp686K23225; putative RAS binding protein; RASSF6 antibody; Ras association (RalGDS/AF-6) domain family 6 antibody; DKFZp686K23225 antibody; putative RAS binding protein antibody
other names :
ras association domain-containing protein 6 isoform a; Ras association domain-containing protein 6; ras association domain-containing protein 6; Ras association domain family member 6
products gene name :
RASSF6
other gene names :
RASSF6; RASSF6
uniprot entry name :
RASF6_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human
sequence :
SNTLKPHAKDEPDS
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 45kDa band observed in lysates of cell line HepG2 (calculated MW of 43.4kDa according to NP_958834.1). Recommended concentration: 1-3ug/ml.
other info1 :
Immunogen: Peptide with sequence C-SNTLKPHAKDEPDS, from the internal region of the protein sequence according to NP_803876.1; NP_958834.1. Epitope: Internal region
other info2 :
Note: This antibody is expected to recognise both reported isoforms (NP_803876.1; NP_958834.1).
ncbi acc num :
NP_803876.1
ncbi gb acc num :
NM_177532.4
ncbi mol weight :
35,809 Da
ncbi pathways :
Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388)
ncbi summary :
This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
uniprot summary :
RASSF6: Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B. 4 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 4q13.3. Molecular Function: protein binding. Biological Process: apoptosis; signal transduction