catalog number :
MBS421586
products full name :
Goat anti-RAB8A Antibody
products short name :
RAB8A
products name syn :
RAB8A; RAB8A; member RAS oncogene family; MEL; RAB8; mel transforming oncogene; mel transforming oncogene (RAB8 homolog); mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; ras-associated protein RAB8; RAB8A; RAB8A, member RAS oncogene family; MEL; RAB8; mel transforming oncogene; mel transforming oncogene (RAB8 homolog); mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; ras-associated protein RAB8
other names :
ras-related protein Rab-8A; Ras-related protein Rab-8A; ras-related protein Rab-8A; oncogene c-mel; ras-associated protein RAB8; mel transforming oncogene (RAB8 homolog); mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; RAB8A, member RAS oncogene family; Oncogene c-mel
products gene name :
RAB8A
other gene names :
RAB8A; RAB8A; MEL; RAB8; MEL; RAB8
uniprot entry name :
RAB8A_HUMAN
reactivity :
Human, Dog, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 25kDa band observed in Human Brain (Cerebellum), Kidney and Heart lysates (calculated MW of 23.7kDa according to NP_005361.2). Recommended concentration: 0.1-0.3ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-NQGVKITPDQQKR, from the C Terminus of the protein sequence according to NP_005361.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS426539
ncbi acc num :
NP_005361.2
ncbi gb acc num :
NM_005370.4
ncbi mol weight :
23,564 Da
ncbi pathways :
AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!G2/M Transition Pathway 105801!!Membrane Trafficking Pathway 106160!!Mitotic G2-G2/M Phases Pathway 160942!!Pancreatic Secretion Pathway 169306!!Pancreatic Secretion Pathway 169295!!Regulation Of PLK1 Activity At G2/M Transition Pathway 771569
ncbi summary :
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]