catalog number :
MBS421585
products full name :
Goat anti-Urocortin 3 Antibody
products short name :
Urocortin 3
products name syn :
UCN3; urocortin 3 (stresscopin); MGC119002; SCP; SPC; UCNIII; stresscopin; urocortin 3; urocortin III; UCN3 antibody; urocortin 3 (stresscopin) antibody; MGC119002 antibody; SCP antibody; SPC antibody; UCNIII antibody; stresscopin antibody; urocortin 3 antibody; urocortin III antibody; Urocortin 3; Urocortin 3
other names :
urocortin-3 preproprotein; Urocortin-3; urocortin-3; urocortin 3; Stresscopin; Urocortin III; Ucn III
products gene name :
UCN3
other gene names :
UCN3; UCN3; SCP; SPC; UCNIII; SPC; Ucn III
uniprot entry name :
UCN3_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human
sequence :
KPRQDTAKSPHRTK
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: In transfected HEK293 transiently expressing full-length Human UCN3 (myc and DYKDDDDK tagged), a band of approx.19kDa was observed. No bands were observed in mock-transfected HEK293 and the same band was observed using anti-DYKDDDDK tag antibody. Recommended concentration, 1- 2ug/ml.
other info1 :
Immunogen: Peptide with sequence C-KPRQDTAKSPHRTK, from the internal region of the protein sequence according to NP_444277.2. Epitope: Internal region
ncbi acc num :
NP_444277.2
ncbi gb acc num :
NM_053049.3
ncbi mol weight :
17,961 Da
ncbi summary :
This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]
uniprot summary :
UCN3: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 10p15.1. Cellular Component: extracellular space. Molecular Function: corticotropin-releasing hormone receptor 2 binding; G-protein-coupled receptor binding; hormone activity. Biological Process: cellular response to nutrient levels; digestion; G-protein signaling, adenylate cyclase activating pathway; response to stress