catalog number :
MBS421571
products full name :
Goat anti-GLIPR1/RTVP-1 Antibody
products short name :
GLIPR1/RTVP-1
products name syn :
GLIPR1; GLI pathogenesis-related 1 (glioma); RTVP-1; CRISP7; GLIPR; RTVP1; glioma pathogenesis-related protein; glioma pathogenesis-related protein 1; related to testis-specific, vespid, and pathogenesis proteins 1; testes-specific vespid and pathogenesis; GLIPR1 antibody; GLI pathogenesis-related 1 (glioma) antibody; RTVP-1 antibody; CRISP7 antibody; GLIPR antibody; RTVP1 antibody; glioma pathogenesis-related protein antibody; glioma pathogenesis-related protein 1 antibody; related to testis-specific; vespid; and pathogenesis proteins 1 antibody; testes-specific vespid and pathogenesis protei antibody; GLIPR1 / RTVP-1
other names :
glioma pathogenesis-related protein 1; Glioma pathogenesis-related protein 1; glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Protein RTVP-1
products gene name :
GLIPR1
products gene name syn :
RTVP-1
other gene names :
GLIPR1; GLIPR1; GLIPR; RTVP1; CRISP7; GLIPR; RTVP1; GliPR 1
uniprot entry name :
GLIP1_HUMAN
reactivity :
Expected from sequence similarity: Human
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Preliminary experiments gave an approx 40kDa band in human prostate lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 30.4kDa according to NP_006842.2. The ~40kDa band was successfully blocked by incubation with the immunizing peptide.
other info1 :
Immunogen: Peptide with sequence C-NRQRDQVKRYYS, from the internal region of the protein sequence according to NP_006842.2. Epitope: Internal region
ncbi acc num :
NP_006842.2
ncbi gb acc num :
NM_006851.2
ncbi mol weight :
26,919 Da
ncbi pathways :
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (1270010); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); PPARA Activates Gene Expression Pathway (1270030); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (1270029)
ncbi summary :
This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
uniprot summary :
GLIPR1: a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 12q21.2. Cellular Component: extracellular region; integral to membrane; membrane; plasma membrane