catalog number :
MBS421561
products full name :
Goat anti-CLEC16A Antibody
products short name :
CLEC16A
products name syn :
Goat Anti-CLEC16A (aa1040-53) Antibody; CLEC16A; C-type lectin domain family 16, member A; Gop-1; KIAA0350; MGC111457; CLEC16A antibody; C-type lectin domain family 16; member A antibody; Gop-1 antibody; KIAA0350 antibody; MGC111457 antibody
other names :
protein CLEC16A isoform 1; Protein CLEC16A; protein CLEC16A; C-type lectin domain family 16 member A; C-type lectin domain family 16 member A
products gene name :
CLEC16A
other gene names :
CLEC16A; CLEC16A; Gop-1; KIAA0350
uniprot entry name :
CL16A_HUMAN
reactivity :
Expected from sequence similarity: Human, Mouse, Rat
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Preliminary experiments gave an approx 70kDa band in rat testis lysates after 0.5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 115kDa according to XP_213209.4 predicted in Rat and 118kDa in Human NP_056041.1. The 70kDa band was successfully blocked by incubation with the immunizing peptide.
other info1 :
Immunogen: Peptide with sequence C-SLENQDKGGERP, from the internal region of the protein sequence according to NP_056041.1. Epitope: Internal region
ncbi acc num :
NP_056041.1
ncbi gb acc num :
NM_015226.2
ncbi mol weight :
14,283 Da
ncbi summary :
This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
uniprot summary :
CLEC16A: Insulin-dependent diabetes mellitus is significantly associated with variation within a 233-kb linkage disequilibrium block on chromosome 16p13 that includes KIAA0350. Three common non-coding variants of KIAA0350 in strong linkage disequilibrium reach genome-wide significance for association with the disease (PubMed:17632545). Belongs to the CLEC16A/gop-1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Unknown function. Chromosomal Location of Human Ortholog: 16p13.13. Cellular Component: endosome membrane; lysosomal membrane. Biological Process: autophagy