antibody

Goat anti-Neurexin 1 Antibody

MBS421542

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog

western blot, enzyme immunoassay

Antibody

Goat anti-Neurexin 1 Antibody

Neurexin 1

neurexin 1; DKFZp313P2036; NRXN1; FLJ35941; Hs.22998; KIAA0578; neurexin I; neurexin 1 antibody; DKFZp313P2036 antibody; NRXN1 antibody; FLJ35941 antibody; Hs.22998 antibody; KIAA0578 antibody; neurexin I antibody; Neurexin 1; Neurexin 1

neurexin-1 isoform alpha1; Neurexin-1; neurexin-1; neurexin 1; Neurexin I-alpha; Neurexin-1-alpha

NRXN1

NRXN1; NRXN1; PTHSL2; SCZD17; Hs.22998; KIAA0578

NRX1A_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog

1477

KEKQPSSAKSSNKN

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: In transfected HEK293 transiently expressing full-length Human NRXN1 (myc and DYKDDDDK tagged), bands of approx.75 and 60kDa were observed. No bands were observed in mock-transfected HEK293 and the same band was observed using anti-DYKDDDDK tag antibody. Recommended concentration, 0.5-1ug/ml.

Immunogen: Peptide with sequence C-KEKQPSSAKSSNKN, from the C Terminus of the protein sequence according to NP_004792.1 ; NP_620072.1. Epitope: C Terminus

Note: This antibody is expected to recognise both reported isoforms (NP_004792.1 and NP_620072.1).

14149613

NP_004792.1

NM_004801.4

46,861 Da

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Extracellular Matrix Organization Pathway (1270244); Non-integrin Membrane-ECM Interactions Pathway (1270254)

This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission, and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. The RefSeq project has decided to create only a few representative transcript variants of the multitude that are possible. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2. [provided by RefSeq, Feb 2016]

0.1 mg

300 USD