catalog number :
MBS421520
products full name :
Goat anti-Collagen, type VII Antibody
products short name :
Collagen
products name syn :
Collagen; type VII; collagen; type VII; alpha 1 (epidermolysis bullosa; dystrophic; dominant and recessive); COL7A1; HGNC:2214; EBD1; EBDCT; EBR1; LC collagen; alpha 1 type VII collagen; collagen VII; alpha-1 polypeptide; long chain collagen; collagen; type VII; alpha 1; Collagen, type VII; collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive); COL7A1; HGNC:2214; EBD1; EBDCT; EBR1; LC collagen; alpha 1 type VII collagen; collagen VII; alpha-1 polypeptide; long chain collagen; collagen, type VII, alpha 1
other names :
collagen alpha-1(VII) chain; Collagen alpha-1(VII) chain; collagen alpha-1(VII) chain; collagen alpha-1(VII) chain; LC collagen; long-chain collagen; collagen VII, alpha-1 polypeptide; collagen, type VII, alpha 1; Long-chain collagen; LC collagen
products gene name :
COL7A1
other gene names :
COL7A1; COL7A1; EBD1; EBR1; EBDCT; NDNC8; LC collagen
uniprot entry name :
CO7A1_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 250kDa band observed in rat testis lysates (calculated MW of 159kDa according to Rat NP_001100328.1). Recommended concentration: 0.1-1.5ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-TVQYSDDPRTEF, from the internal region of the protein sequence according to NP_000085.1. Corresponding Immunizing Peptide: Catalog #MBS426106
other info2 :
Important Note: This product does not work on cryostat sections of Normal Human Skin.
ncbi acc num :
NP_000085.1
ncbi gb acc num :
NM_000094.3
ncbi mol weight :
292,267 Da
ncbi pathways :
Anchoring Fibril Formation Pathway 730307!!Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway 730306!!Collagen Biosynthesis And Modifying Enzymes Pathway 645289!!Collagen Formation Pathway 645288!!Extracellular Matrix Organization Pathway 576262!!Protein Digestion And Absorption Pathway 172847!!Protein Digestion And Absorption Pathway 171868
ncbi summary :
This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008]