catalog number :
MBS421496
products full name :
Goat anti-CLLD8 / SETDB2 Antibody
products short name :
CLLD8/SETDB2
products name syn :
SETDB2; CLLD8; SET domain; bifurcated 2; CLLL8 protein; C13orf4; CLLL8; DKFZp586I0123; DKFZp761J1217; KMT1F; chronic lymphocytic leukemia deletion region 8; lysine N-methyltransferase 1F; histone-lysine N-methyltransferase SETDB2; Goat Anti-SETDB2; SETDB2; CLLD8; SET domain, bifurcated 2; CLLL8 protein; C13orf4; CLLL8; DKFZp586I0123; DKFZp761J1217; KMT1F; chronic lymphocytic leukemia deletion region 8; lysine N-methyltransferase 1F; histone-lysine N-methyltransferase SETDB2
other names :
histone-lysine N-methyltransferase SETDB2 isoform a; Histone-lysine N-methyltransferase SETDB2; histone-lysine N-methyltransferase SETDB2; lysine N-methyltransferase 1F; chronic lymphocytic leukemia deletion region 8; chronic lymphocytic leukemia deletion region gene 8 protein; SET domain, bifurcated 2; Chronic lymphocytic leukemia deletion region gene 8 protein; Lysine N-methyltransferase 1F; SET domain bifurcated 2
products gene name :
SETDB2
other gene names :
SETDB2; SETDB2; CLLD8; CLLL8; KMT1F; C13orf4; C13orf4; CLLD8; KMT1F
uniprot entry name :
SETB2_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 80kDa band observed in Human Heart lysates (calculated MW of 81.9kDa according to NP_114121.1). Recommended concentration: 1.5-4.5ug/ml.
This product is not suitable in WB on Mouse Heart and Rat Heart lysates. Peptide ELISA: antibody detection limit dilution 1:8000.
other info1 :
Epitope: N Terminus. Immunogen: Peptide with sequence GEKNGDAKTFWME-C, from the N Terminus of the protein sequence according to NP_114121.2; NP_001153780.1. Corresponding Immunizing Peptide: Catalog #MBS428287
other info2 :
Important Note: This antibody is expected to recognize both reported isoforms (NP_114121.2; NP_001153780.1).
ncbi acc num :
NP_114121.2
ncbi gb acc num :
NM_031915.2
ncbi mol weight :
81,766 Da
ncbi pathways :
Lysine Degradation Pathway 82956!!Lysine Degradation Pathway 320
ncbi summary :
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM, Mar 2008]