catalog number :
MBS421491
products full name :
Goat anti-Catalase / CAT Antibody
products short name :
Catalase/CAT
products name syn :
CAT; catalase; HGNC:1516; MGC138422; MGC138424; CAT; catalase; HGNC:1516; MGC138422; MGC138424
other names :
catalase; Catalase; catalase; catalase
other gene names :
CAT; CAT
uniprot entry name :
CATA_HUMAN
reactivity :
Human, Mouse, Dog, Rat
sequence :
DKYNAEKPKNAIHT
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Immunohistochemistry: Immunohistochemistry: In paraffin embedded Human Liver shows vesicular staining in the cytoplasm of hepatocytes. Recommended concentration, 2-4ug/ml. Western Blot: Approx 60kDa band observed in Human, Mouse and Rat Kidney and Liver lysates (calculated MW of 59.8kDa according to NP_001743.1). Recommended concentration: 0.3-1ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-DKYNAEKPKNAIHT, from the internal region of the protein sequence according to NP_001743.1.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS426759
ncbi acc num :
NP_001743.1
ncbi gb acc num :
NM_001752.3
ncbi mol weight :
59,756 Da
ncbi pathways :
Amyotrophic Lateral Sclerosis (ALS) Pathway 920975!!Amyotrophic Lateral Sclerosis (ALS) Pathway 83099!!Amyotrophic Lateral Sclerosis (ALS) Pathway 511!!Cellular Responses To Stress Pathway 645258!!DNA Damage Response (only ATM Dependent) Pathway 198827!!Detoxification Of Reactive Oxygen Species Pathway 941400!!Folate Metabolism Pathway 198833!!FoxO Family Signaling Pathway 138036!!FoxO Signaling Pathway 921162!!Glyoxylate And Dicarboxylate Metabolism Pathway 83002
ncbi summary :
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]