Goat anti-Aromatase/CYP19A1 Antibody | MyBioSource MBS421466 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Aromatase/CYP19A1 Antibody

catalog :

MBS421466

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS421466

products type :

Antibody

products full name :

Goat anti-Aromatase/CYP19A1 Antibody

products short name :

Aromatase/CYP19A1

products name syn :

CYP19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; ARO; ARO1; CPV1; CYAR; CYP19; MGC104309; P-450AROM; aromataseN: cytochrome P450, family 19; cytochrome P450, subfamily XIX (aromatization of androgens); estrogen synthetase; flavoprotein-li; CYP19A1 antibody; cytochrome P450; family 19; subfamily A; polypeptide 1 antibody; ARO antibody; ARO1 antibody; CPV1 antibody; CYAR antibody; CYP19 antibody; MGC104309 antibody; P-450AROM antibody; aromataseN: cytochrome P450; family 19 antibody; cytochrome P450; subfamily XIX (aromatization of androgens) antibody; estrogen synthetase antibody; flavoprotein-linked monooxygenase antibody; microsomal monooxygenase antibody; Aromatase; Aromatase / CYP19A1

other names :

aromatase; Aromatase; aromatase; cytochrome P450 family 19 subfamily A member 1; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase

products gene name :

CYP19A1

other gene names :

CYP19A1; CYP19A1; ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM; ARO1; CYAR; CYP19

uniprot entry name :

CP19A_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human

sequence length :

503

sequence :

HDLSLHPDETKN

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Approx 50-55kDa band observed in Human Placenta lysates (calculated MW of 57.9kDa according to NP_000094.2 and NP_112503.1). Recommended concentration: 0.1-0.3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-HDLSLHPDETKN, from the internal region of the protein sequence according to NP_000094.2; NP_112503.1. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognise both reported isoforms (NP_000094.2 and NP_112503.1), which are identical

ncbi gi num :

13904858

ncbi acc num :

NP_000094.2

ncbi gb acc num :

NM_000103.3

ncbi mol weight :

24,518 Da

ncbi pathways :

Biological Oxidations Pathway (1270189); C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway (413383); C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway (468268); Cytochrome P450 - Arranged By Substrate Type Pathway (1270191); Endogenous Sterols Pathway (1270192); Estrogen Biosynthesis Pathway (1270051); FSH Signaling Pathway (672455); Integrated Breast Cancer Pathway (219801); Metabolic Pathways (132956); Metabolism Pathway (1269956)

ncbi summary :

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

uniprot summary :

CYP19A1: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family. Protein type: Lipid Metabolism - androgen and estrogen; EC 1.14.14.14; Oxidoreductase. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane. Molecular Function: electron carrier activity; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding; steroid hydroxylase activity. Biological Process: androgen metabolic process; estrogen biosynthetic process; negative regulation of chronic inflammatory response; steroid biosynthetic process; sterol metabolic process. Disease: Aromatase Deficiency; Aromatase Excess Syndrome

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage