catalog number :
MBS421454
products full name :
Goat anti-DLC1 (Isoforms 1 and 3) Antibody
products short name :
DLC1
products name syn :
DLC1; HP; ARHGAP7; STARD12; FLJ21120; p122-RhoGAP; deleted in liver cancer 1; Rho-GTPase-activating protein 7; START domain containing protein 12; StAR-related lipid; transfer protein 12; StAR-related lipid transfer (START) domain containing 12; deleted; DLC1 antibody; HP antibody; ARHGAP7 antibody; STARD12 antibody; FLJ21120 antibody; p122-RhoGAP antibody; deleted in liver cancer 1 antibody; Rho-GTPase-activating protein 7 antibody; START domain containing protein 12 antibody; StAR-related lipid transfer protein 12 antibody; StAR-related lipid transfer (START) domain containing 12 antibody; deleted in liver cancer 1 variant 2 antibody; DLC1 (Isoforms 1 and 3)
other names :
rho GTPase-activating protein 7 isoform 1; Rho GTPase-activating protein 7; rho GTPase-activating protein 7; DLC1 Rho GTPase activating protein; Deleted in liver cancer 1 protein; DLC-1; HP protein; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StARD12; StAR-related lipid transfer protein 12
products gene name :
DLC1
other gene names :
DLC1; DLC1; HP; ARHGAP7; STARD12; p122-RhoGAP; ARHGAP7; KIAA1723; STARD12; DLC-1; StARD12
uniprot entry name :
RHG07_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human, Mouse, Pig
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 32000. Immunohistochemistry: In paraffin embedded Human Adrenal Gland (Medulla) shows strong reticulate staining in the cytoplasm of medular cells. Recommended concentration, 5ug/ml. Western Blot: This antibody has been successfully used in WB for human heart as described in the following paper: Ko et al, Liver Int.2010 Jan;30(1): 139-48.; PMID: 19874489.
other info1 :
Immunogen: Peptide with sequence SVAIRKRSWEEHC, from the N Terminus of the protein sequence according to NP_872584.2; NP_079043.3. Epitope: N Terminus
other info2 :
Note: This antibody is expected to recognise isoforms 1 and 3 (NP_872584.2 and NP_079043.3 resp) but NOT isoform 2 (NP_006085.2).
ncbi acc num :
NP_872584.2
ncbi gb acc num :
NM_182643.2
ncbi mol weight :
126,746 Da
ncbi pathways :
Regulation Of RhoA Activity Pathway (138070); Rho GTPase Cycle Pathway (1269508); Signal Transduction Pathway (1269379); Signaling By Rho GTPases Pathway (1269507)
ncbi summary :
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]