catalog number :
MBS421446
products full name :
Goat anti-AHI1 / Jouberin Antibody
products short name :
AHI1/Jouberin
products name syn :
AHI1; AHI-1; DKFZp686J1653; FLJ14023; FLJ20069; JBTS3; ORF1; dJ71N10.1; Abelson helper integration site; jouberin; Ahi-1 isoform I; OTTHUMP00000017263; OTTHUMP00000017264; OTTHUMP00000017265; contatins SH3 and WD40 domains; AHI-1; DKFZp686J1653; FLJ14023; FLJ20069; JBTS3; ORF1; dJ71N10.1; Abelson helper integration site; jouberin; Ahi-1 isoform I; OTTHUMP00000017263; OTTHUMP00000017264; OTTHUMP00000017265; contatins SH3 and WD40 domains; Abelson helper integration site 1
other names :
jouberin isoform a; Jouberin; jouberin; contatins SH3 and WD40 domains; abelson helper integration site 1 protein homolog; Abelson helper integration site 1; Abelson helper integration site 1 protein homolog; AHI-1
products gene name :
AHI1
other gene names :
AHI1; AHI1; ORF1; AHI-1; JBTS3; dJ71N10.1; AHI-1
uniprot entry name :
AHI1_HUMAN
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Western Blot: Preliminary experiments gave an approx 22kDa band in Human Brain lysates after 0.1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 137kDa according to NP_060121.3. The 22kDa band was successfully blocked by incubation with the immunizing peptide. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: N Terminus. Immunogen: Peptide with sequence PTAESEAKVKTC, from the N Terminus of the protein sequence according to NP_060121.3; NP_001128303.1; NP_001128302.1; NP_001128304.1. Corresponding Immunizing Peptide: Catalog #MBS425311
other info2 :
Important Note: This antibody is expected to recognise both reported isoforms. Variants (NP_060121.3; NP_001128303.1; NP_001128302.1) encode the same isofom.
products references :
Kennah E, Ringrose A, Zhou LL, Esmailzadeh S, Qian H, Su MW, Zhou Y, Jiang X.; Identification of tyrosine kinase, HCK, and tumor suppressor, BIN1, as potential mediators of AHI-1 oncogene in primary and transformed CTCL cells.; Blood. 2009 May 7; 113(19):4646-55.; Pubmed 19211505
ncbi acc num :
NP_060121.3
ncbi gb acc num :
NM_017651.4
ncbi mol weight :
70,047 Da
ncbi summary :
This gene is apparently required for both cerebellar and cortical development in humans. This gene mutations cause specific forms of Joubert syndrome-related disorders. Joubert syndrome (JS) is a recessively inherited developmental brain disorder with several identified causative chromosomal loci. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]