catalog number :
MBS421436
products full name :
Goat anti-GDF15 Antibody
products short name :
GDF15
products name syn :
GDF15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; growth differentiation factor 15; PTGF-beta; prostate differentiation factor; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; GDF15 antibody; PDF antibody; MIC1 antibody; PLAB antibody; MIC-1 antibody; NAG-1 antibody; PTGFB antibody; GDF-15 antibody; growth differentiation factor 15 antibody; PTGF-beta antibody; prostate differentiation factor antibody; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1 antibody
other names :
growth/differentiation factor 15 preproprotein; Growth/differentiation factor 15; growth/differentiation factor 15; growth differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor
products gene name :
GDF15
other gene names :
GDF15; GDF15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; MIC1; PDF; PLAB; PTGFB; GDF-15; MIC-1; NAG-1; NRG-1
uniprot entry name :
GDF15_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat
sequence :
QKTDTGVSLQTYDD
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 2000. Western Blot: Approx 35 kDa band observed in Human Prostate lysates (calculated MW of 34.1kDa according to NP_004855.1). In transfected HEK293 transiently expressing GDF15 a band of approx.35 kDa is observed. This band is not observed in the non-transfected HEK293. Recommended concentration: 0.1-0.3ug/ml.
other info1 :
Immunogen: Peptide with sequence C-QKTDTGVSLQTYDD, from the C Terminus of the protein sequence according to NP_004855.2. Epitope: C Terminus
ncbi acc num :
NP_004855.2
ncbi gb acc num :
NM_004864.2
ncbi mol weight :
34,140 Da
ncbi pathways :
Direct P53 Effectors Pathway (137939)
ncbi summary :
The protein encoded by this gene belongs to the transforming growth factor-beta (TGF-beta) family. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress reponse program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Sep 2015]
uniprot summary :
GDF15: disulfide-linked. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide; Cytokine. Chromosomal Location of Human Ortholog: 19p13.11. Cellular Component: extracellular region; extracellular space. Molecular Function: cytokine activity; growth factor activity; transforming growth factor beta receptor binding. Biological Process: cell development; cell-cell signaling; regulation of apoptosis; regulation of MAPKKK cascade; signal transduction; transforming growth factor beta receptor signaling pathway