product summary
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company name :
MyBioSource
product type :
antibody
product name :
Goat anti-VPS11 Antibody
catalog :
MBS421433
quantity :
0.1 mg
price :
300 USD
clonality :
polyclonal
host :
goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dog, cow
application :
immunohistochemistry, enzyme immunoassay
more info or order :
product information
catalog number :
MBS421433
products type :
Antibody
products full name :
Goat anti-VPS11 Antibody
products short name :
VPS11
products name syn :
VPS11; vacuolar protein sorting 11 (yeast); HGNC: 14583; END1; PEP5; RNF108; hVPS11; vacuolar protein sorting 11 (yeast homolog); vacuolar protein sorting protein 11; vacuolar protein sorting 11 homolog (S. cerevisiae); VPS11 antibody; vacuolar protein sorting 11 (yeast) antibody; HGNC: 14583 antibody; END1 antibody; PEP5 antibody; RNF108 antibody; hVPS11 antibody; vacuolar protein sorting 11 (yeast homolog) antibody; vacuolar protein sorting protein 11 antibody; vacuolar protein sorting 11 homolog (S. cerevisiae) antibody
other names :
vacuolar protein sorting-associated protein 11 homolog isoform 1; Vacuolar protein sorting-associated protein 11 homolog; vacuolar protein sorting-associated protein 11 homolog; VPS11, CORVET/HOPS core subunit; RING finger protein 108
products gene name :
VPS11
other gene names :
VPS11; VPS11; END1; PEP5; HLD12; RNF108; hVPS11; RNF108; hVPS11
uniprot entry name :
VPS11_HUMAN
clonality :
Polyclonal
host :
Goat
reactivity :
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
sequence length :
941
sequence :
HALQEKDTQTKLE
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunohistochemistry (IHC)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 32000. Immunohistochemistry: In paraffin embedded Human Kidney shows brushborder staning in PCT cells and Human Pancreas shows cytoplasm staining of beta cells in islets of Langerhans. Recommended concentration, 3-6ug/ml. Western Blot: Preliminary experiments gave an approx 75kDa band in human duodenum, colon and placenta lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 108kDa according to NP_068375.3. The 75kDa band was successfully blocked by incubation with the immunizing peptide.
other info1 :
Immunogen: Peptide with sequence C-HALQEKDTQTKLE, from the internal region of the protein sequence according to NP_068375.3. Epitope: Internal region
ncbi gi num :
17978477
ncbi acc num :
NP_068375.3
ncbi gb acc num :
NM_021729.5
ncbi mol weight :
107,837 Da
ncbi summary :
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
uniprot summary :
VPS11: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Belongs to the VPS11 family. Protein type: Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 11q23. Cellular Component: autophagic vacuole; clathrin-coated vesicle; early endosome; endocytic vesicle; endosome; late endosome; late endosome membrane; lysosomal membrane; lysosome. Molecular Function: nucleotide binding; protein binding; protein binding, bridging; protein domain specific binding; syntaxin binding; zinc ion binding. Biological Process: autophagy; endosomal vesicle fusion; endosome organization and biogenesis; endosome to lysosome transport; intracellular protein transport; lysosome organization and biogenesis; regulation of protein stability; vesicle docking during exocytosis
size1 :
0.1 mg
price1 :
300 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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