catalog number :
MBS421427
products full name :
Goat anti-DKK1 Antibody
products short name :
DKK1
products name syn :
DKK1; SK; DKK-1; dickkopf homolog 1 (Xenopus laevis); dickkopf-1 like; dickkopf (Xenopus laevis) homolog 1; dickkopf homolog 1; dickkopf related protein-1; DKK1; SK; DKK-1; dickkopf homolog 1 (Xenopus laevis); dickkopf-1 like; dickkopf (Xenopus laevis) homolog 1; dickkopf homolog 1; dickkopf related protein-1
other names :
dickkopf-related protein 1; Dickkopf-related protein 1; dickkopf-related protein 1; hDkk-1; dickkopf-1 like; dickkopf 1 homolog; dickkopf-like protein 1; dickkopf related protein-1; dickkopf WNT signaling pathway inhibitor 1; SK
products gene name :
DKK1
other gene names :
DKK1; DKK1; SK; DKK-1; Dickkopf-1; Dkk-1; hDkk-1
uniprot entry name :
DKK1_HUMAN
reactivity :
Human, Rat, Dog, Pig, Cow
sequence :
CDHHQASNSSRLHT
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 38kDa band observed in Human Spleen ysates (calculated MW of 28.7kDa according to NP_036374.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Fedi et al, J Biol Chem. 1999 Jul 2;274(27):19465-72; PMID: 10383463). Recommended concentration: 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:128000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence CDHHQASNSSRLHT, from the C Terminus of the protein sequence according to NP_036374.1.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS426796
ncbi acc num :
NP_036374.1
ncbi gb acc num :
NM_012242.2
ncbi mol weight :
28,672 Da
ncbi pathways :
Cardiac Progenitor Differentiation Pathway 712094!!Direct P53 Effectors Pathway 137939!!Disease Pathway 530764!!Presenilin Action In Notch And Wnt Signaling Pathway 137914!!RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway 1016209!!Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway 169352!!Signal Transduction Pathway 477114!!Signaling By WNT In Cancer Pathway 1016191!!Signaling By Wnt Pathway 106510!!TCF Dependent Signaling In Response To WNT Pathway 980475
ncbi summary :
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]