antibody

Goat anti-NKG2D / KLRK1 Antibody

MBS421411

0.1 mg

290 USD

polyclonal

goat

nonconjugated

western blot, enzyme immunoassay

Antibody

Goat anti-NKG2D / KLRK1 Antibody

NKG2D/KLRK1

KLRK1; NKG2-D; killer cell lectin-like receptor subfamily K; member 1; HGNC:18788; D12S2489E; KLR; NK cell receptor D; NKG2-D type II integral membrane protein; CD314; D12S2489E; FLJ17759; FLJ75772; NKG2D; KLRK1; NKG2-D; killer cell lectin-like receptor subfamily K, member 1; HGNC:18788; D12S2489E; KLR; NK cell receptor D; NKG2-D type II integral membrane protein; CD314; D12S2489E; FLJ17759; FLJ75772; NKG2D

NKG2-D type II integral membrane protein; NKG2-D type II integral membrane protein; NKG2-D type II integral membrane protein; NK cell receptor D; NKG2-D-activating NK receptor; killer cell lectin-like receptor subfamily K, member 1; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD_antigen: CD314

KLRK1

KLRK1; KLRK1; KLR; CD314; NKG2D; NKG2-D; D12S2489E; D12S2489E; NKG2D

NKG2D_HUMAN

Polyclonal

Goat

Human, Mouse, Rat

216

KVYSKEDQDLLK

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Western Blot: Approx 35kDa band observed in human lymph node and human spleen lysates (calculated MW of 25.3kDa according to NP_031386.1). The observed molecular weight is explained by glycosylation (Han et al, Blood. 2004 Nov 1;104(9):2858-66. Epub 2004 Jul 6; PMID: 15238421). Recommended concentration: 0.1-0.3ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.

Epitope: Internal Region. Immunogen: Peptide with sequence C-KVYSKEDQDLLK, from the internal region of the protein sequence according to NP_031386.2.

Corresponding Immunizing Peptide: Catalog #MBS426409

169234653

NP_031386.2

NM_007360.3

25,274 Da

Adaptive Immune System Pathway 366160!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550!!Immune System Pathway 106386!!Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway 106413!!Innate Immune System Pathway 106387!!Malaria Pathway 152665!!Malaria Pathway 152657!!Natural Killer Cell Mediated Cytotoxicity Pathway 83079!!Natural Killer Cell Mediated Cytotoxicity Pathway 490

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]

0.1 mg

290 USD